Evidence map›Paper›PMID 35711417›Full record

Trial reportFrontiers in immunology2022

Characteristics of Prognostic Programmed Cell Death-Related Long Noncoding RNAs Associated With Immune Infiltration and Therapeutic Responses to Colon Cancer.

Yan Chen, Yue Zhang, Jiayi Lu, Zhongchen Liu, Shasha Zhao, Mengmei Zhang, Mingzhi Lu, Wen Xu, Fenyong Sun, Qi Wu and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Noncoding RNA, friend or foe for nephrolithiasis?Frontiers in cell and developmental biology · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yan ChenDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yue ZhangDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Jiayi LuDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Zhongchen LiuDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to TongJi University, Shanghai, China.
Shasha ZhaoDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Mengmei ZhangDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Mingzhi LuDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Wen XuDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Fenyong SunDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Qi WuDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Qi ZhongDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Zhongqi CuiDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Tongji University · CNShanghai Tenth People's Hospital · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmed cell death (PCD) plays an important role in the onset and progression of various cancers. The molecular events surrounding the occurrence of abnormally expressed long noncoding RNAs (lncRNAs) leading to colon cancer (CC) have become a focus. We comprehensively evaluated the roles of PCD-related lncRNAs in the clinical management of CC and their immune responses. Therefore, we screened 41 prognostic PCD-related lncRNAs in The Cancer Genome Atlas database using co-expression analysis and assigned patients to groups according to the results of cluster analysis. The immune response and functions of cluster 2 were substantially suppressed, which might explain the poor prognosis in this group. A prognostic model comprising eight PCD-related lncRNAs was developed, and its effectiveness was verified using an external database. High-and low-risk groups had different epigenetic modifications and changes in immune cell infiltration. Patients in the high-risk group were resistant to immunotherapy and various chemotherapeutic drugs. Studies

Indexed as

Colonic NeoplasmsRNA, Long NoncodingApoptosisBiomarkers, TumorGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansPrognosisBiomarkers, TumorRNA, Long Noncodingcolon cancerimmune infiltrationlncRNAprogrammed cell deaththerapeutic responseTMB

Identifiers

PMID35711417
PMCPMC9195301
OpenAlexW4282008940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.