Evidence map›Paper›PMID 35711381›Full record

ArticleFrontiers in cardiovascular medicine2022

Brief Research Report: Quantitative Analysis of Potential Coronary Microvascular Disease in Suspected Long-COVID Syndrome.

Patrick Doeblin, Fridolin Steinbeis, Cian M Scannell, Collin Goetze, Sarah Al-Tabatabaee, Jennifer Erley, Alessandro Faragli, Felix Pröpper, Martin Witzenrath, Thomas Zoller and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. High-resolution quantification of stress perfusion defects by cardiac magnetic resonance.European heart journal. Imaging methods and practice · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 4 countries.

Patrick DoeblinDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Fridolin SteinbeisDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Cian M ScannellSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Collin GoetzeDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Sarah Al-TabatabaeeDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Jennifer ErleyDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Alessandro FaragliDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Felix PröpperDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Martin WitzenrathDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Thomas ZollerDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Christian StehningClinical Science, Philips Healthcare, Hamburg, Germany.
Holger GerhardtGerman Centre for Cardiovascular Research (DZHK), Berlin, Germany.
Javier Sánchez-GonzálezPhilips Healthcare, Madrid, Spain.
Ebraham AlskafSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Titus KühneGerman Centre for Cardiovascular Research (DZHK), Berlin, Germany.
Burkert PieskeDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Carsten TschöpeGerman Centre for Cardiovascular Research (DZHK), Berlin, Germany.
Amedeo ChiribiriSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Sebastian KelleDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany.
Deutsches Herzzentrum der Charité · DEFreie Universität Berlin · DEKing's College London · GBGerman Centre for Cardiovascular Research · DECharité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DEMax Delbrück Center · DEPhilips (Germany) · DEPhilips (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Case series have reported persistent cardiopulmonary symptoms, often termed long-COVID or post-COVID syndrome, in more than half of patients recovering from Coronavirus Disease 19 (COVID-19). Recently, alterations in microvascular perfusion have been proposed as a possible pathomechanism in long-COVID syndrome. We examined whether microvascular perfusion, measured by quantitative stress perfusion cardiac magnetic resonance (CMR), is impaired in patients with persistent cardiac symptoms post-COVID-19. Methods: Our population consisted of 33 patients post-COVID-19 examined in Berlin and London, 11 (33%) of which complained of persistent chest pain and 13 (39%) of dyspnea. The scan protocol included standard cardiac imaging and dual-sequence quantitative stress perfusion. Standard parameters were compared to 17 healthy controls from our institution. Quantitative perfusion was compared to published values of healthy controls. Results: The stress myocardial blood flow (MBF) was significantly lower [31.8 ± 5.1 vs. 37.8 ± 6.0 (μl/g/beat), Conclusion: While we found a significantly reduced microvascular perfusion post-COVID-19 compared to healthy controls, this reduction was not related to symptoms or COVID-19 severity.

Indexed as

CMRCOVID-19long COVID-19 syndromemicrovascular diseasequantitative perfusion

Identifiers

PMID35711381
PMCPMC9197432
OpenAlexW4281775248

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.