Evidence map›Paper›PMID 35711288›Full record

ArticleMaterials today. Bio2022

Targeted regulation of tumor microenvironment through the inhibition of MDSCs by curcumin loaded self-assembled nano-filaments.

Tingting Wang, Jia Wang, Hui Jiang, Mengnan Ni, Yifan Zou, Yanlong Chen, Ting Wu, Dan Ding, Huae Xu, Xiaolin Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  15. CD8Frontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tingting WangThe State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, China.
Jia WangDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211116, China.
Hui JiangDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211116, China.
Mengnan NiDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211116, China.
Yifan ZouThe First Clinical School of Nanjing Medical University, Nanjing, 210029, China.
Yanlong ChenThe First Clinical School of Nanjing Medical University, Nanjing, 210029, China.
Ting WuDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211116, China.
Dan DingState Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education and College of Life Sciences, Nankai University, Tianjin, 300071, China.
Huae XuDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211116, China.
Xiaolin LiDepartment of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Nanjing Medical University · CNJiangsu Province Hospital · CNNanjing University · CNNankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most important reasons underlying the resistance of tumors is the immune suppression induced by cancer cells. Myeloid-derived suppressor cells (MDSCs), which exerts pivotal functions in immunosuppression, is a key participator in tumor microenvironment and a novel target for cancer therapy. Here curcumin (Cur) was employed as a specific MDSCs repressor to inhibit the number and function of MDSCs. Moreover, a novel self-assembled nano-filament system was generated through the conjugation of Cur and a self-assembled peptide.

Indexed as

CurcuminMDSCNano-filamentsSelf-assemble

Identifiers

PMID35711288
PMCPMC9194645
OpenAlexW4281567779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.