ArticleFrontiers in neurology2022
Association of Pre-stroke Frailty With Prognosis of Elderly Patients With Acute Cerebral Infarction: A Cohort Study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Treatment-modifying effects of frailty on stroke reperfusion therapy outcomes: a systematic review and meta-analysis.Age and ageing · 2026Pooled it
- Association between pre-stroke frailty status and stroke risk and impact on outcomes: a systematic review and meta-analysis of 1,660,328 participants.Aging clinical and experimental research · 2024Pooled it
- Role of frailty in predicting outcomes after stroke: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Cost-effectiveness of opportunistic CT versus clinical methods for sarcopenia screening.Skeletal radiology · 2026Article
- Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.International journal of stroke : official journal of the International Stroke Society · 2025Review
- Association between Pre-stroke Frailty and Clinical Outcomes: A Systematic Review and Meta-analysis.Physical therapy research · 2025Review
- A nomogram predictive model for factors influencing prognosis of acute ischemic stroke patients after intravenous thrombolysis.American journal of translational research · 2025Article
- Correlation of serum calprotectin with outcome of acute cerebral infarction.Open medicine (Warsaw, Poland) · 2025Article
- Preexisting cognitive impairment in patients with acute stroke.Frontiers in neurology · 2025Review
- Multidimensional Analysis of Frailty and Its Influencing Factors in Hospitalized Elderly Stroke Patients.Clinical interventions in aging · 2025Article
- Development and validation of a dynamic nomogram for high care dependency during the hospital-family transition periods in older stroke patients.BMC geriatrics · 2024Article
- Impact of Frailty on Healthcare Outcomes after Cardioembolic Ischaemic Stroke Due to Atrial Fibrillation.International journal of environmental research and public health · 2024Article
- Functioning and recovery during stroke rehabilitation: a comparison between pre-stroke frail and non-frail patients.European geriatric medicine · 2023Article
- Effect of admission in the stroke care unit versus intensive care unit on in-hospital mortality in patients with acute ischemic stroke.BMC neurology · 2023Article
- Morphology of paraspinal muscles in frail and non-frail older adults evaluated through FRAIL scale.BMC musculoskeletal disorders · 2023Article
- Association between pre-stroke sarcopenia risk and stroke-associated infection in older people with acute ischemic stroke.Frontiers in medicine · 2023Article
- Neutrophil-to-leukocyte ratio and admission glycemia as predictors of short-term death in very old elderlies with lobar intracerebral hemorrhage.Brain circulationArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a state of cumulative degradation of physiological functions that leads to adverse outcomes such as disability or mortality. Currently, there is still little understanding of the prognosis of pre-stroke frailty status with acute cerebral infarction in the elderly. Objective: We investigated the association between pre-stroke frailty status, 28-day and 1-year survival outcomes, and functional recovery after acute cerebral infarction. Methods: Clinical data were collected from 314 patients with acute cerebral infarction aged 65-99 years. A total of 261 patients completed follow-up in the survival cohort analysis and 215 patients in the functional recovery cohort analysis. Pre-stroke frailty status was assessed using the FRAIL score, the prognosis was assessed using the modified Rankin Scale (mRS), and disease severity using the National Institutes of Health Stroke Scale (NIHSS). Results: Frailty was independently associated with 28-day mortality in the survival analysis cohort [hazard ratio (HR) = 4.30, 95% Conclusions: Pre-stroke frailty is an independent risk factor for 28-day mortality and 28-day or 1-year severe disability. Age, the NIHSS score, and co-infection are likewise independent risk factors for 1-year mortality.
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