ArticlePsychological medicine2023
Multi-modal assessment of reward functioning in adolescent anhedonia.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using AES-SDM.BMC psychiatry · 2026Pooled it
- Human neural correlates of emotional well-being (EWB): a preliminary systematic review and meta-analysis of MRI studies based on a recent consensus definition.Frontiers in human neuroscience · 2025Pooled it
- Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.Molecular psychiatry · 2022Trial
- Using natural language processing to track negative emotions in the daily lives of adolescents.Journal of psychopathology and clinical science · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- The longitudinal relationships between parent-child alienation and depression in adolescents: insights of network analysis.Child and adolescent psychiatry and mental health · 2026Article
- Anhedonia in Depressive Disorder and Schizophrenia: An Overview of Causes, Diagnosis, and Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Multimodal prediction of future depressive symptoms in adolescents.BMC psychiatry · 2025Article
- Multimodal Prediction of Future Depressive Symptoms in Adolescents.Research square · 2025Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study.Schizophrenia bulletin open · 2025Article
- Brain mechanisms of rumination and negative self-referential processing in adolescent depression.Journal of affective disorders · 2024Article
- Dynamic processes in behavioral activation therapy for anhedonic adolescents: Modeling common and patient-specific relations.Journal of consulting and clinical psychology · 2024Article
- Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair.Translational psychiatry · 2024Article
- Safety assessment of deutetrabenazine: real-world adverse event analysis from the FAERS database.Frontiers in pharmacology · 2024Article
- Spontaneous Thought Characteristics are Differentially Related to Heightened Negative Affect vs. Blunted Positive Affect in Adolescents: An Experience Sampling Study.JCPP advances · 2022Article
- Social Media as a Behavioral Activation Tool, Conferring Possible Protection Against Suicidal Thoughts Among Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAnhedonia is a core symptom of depression that predicts worse treatment outcomes. Dysfunction in neural reward circuits is thought to contribute to anhedonia. However, whether laboratory-based assessments of anhedonia and reward-related neural function translate to adolescents' subjective affective experiences in real-world contexts remains unclear.
methodsWe recruited a sample of adolescents (
resultsAnhedonia was associated with lower mean PA and higher mean NA across the 5-day EMA period. Anhedonia was not related to impaired behavioral reward learning, but low PA was associated with reduced nucleus accumbens response during reward anticipation and reduced medial prefrontal cortex (mPFC) response during reward outcome. Greater mean NA was associated with increased mPFC response to loss outcome.
conclusionsTraditional laboratory-based measures of anhedonia were associated with lower subjective PA and higher subjective NA in youths' daily lives. Lower subjective PA and higher subjective NA were associated with decreased reward-related striatal functioning. Higher NA was also related to increased mPFC activity to loss. Collectively, these findings demonstrate that laboratory-based measures of anhedonia translate to real-world contexts and that subjective ratings of PA and NA may be associated with neural response to reward and loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.