ArticleEuropean radiology experimental2022
Twinkling-guided ultrasound detection of polymethyl methacrylate as a potential breast biopsy marker: a comparative investigation.
Article in European radiology experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Passive cavitation detection analysis of materials with varying levels of color Doppler twinkling.Ultrasonics · 2027Article
- Does Color Doppler Twinkling Change Between Ultrasound Platform Generations? - A Comparison Using Breast Biopsy Markers.Academic radiology · 2026Article
- Long-term Migration of Breast Biopsy Markers with and without Mitigating Strategies in an Animal Model.Academic radiology · 2026Article
- Analysis of Color Doppler Twinkling on Breast Biopsy Markers With Hydrostatic Overpressurization and Micro-CT Imaging.Ultrasound in medicine & biology · 2026Article
- Using 3-D-Printed Structures to Evaluate the Potential Causes of the Color Doppler Twinkling Signature.Ultrasound in medicine & biology · 2024Article
- Breast ultrasound knobology and the knobology of twinkling for marker detection.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its first description 25 years ago, color Doppler twinkling has been a compelling ultrasound feature in diagnosing urinary stones. While the fundamental cause of twinkling remains elusive, the distinctive twinkling signature is diagnostically valuable in clinical practice. It can be inferred that if an entity twinkles, it empirically has certain physical features. This work investigates a manipulable polymeric material, polymethyl methacrylate (PMMA), which twinkles and has measurable surface roughness and porosity that likely contribute to twinkling. Comparative investigation of these structural properties and of the twinkling signatures of breast biopsy markers made from PMMA and selected commercially available markers showed how twinkling can improve ultrasound detection of devices intentionally designed to twinkle. While this specific application of detecting breast biopsy markers by twinkling may provide a way to approach an unmet need in the care of patients with breast cancer, this work ultimately provides a platform from which the keys to unlocking the fundamental physics of twinkling can be rigorously explored.
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Registered trials
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