Evidence map›Paper›PMID 35711005›Full record

ArticleThe Journal of infectious diseases2022

Factors Associated With Human IgG Antibody Response to Anopheles albimanus Salivary Gland Extract, Artibonite Department, Haiti, 2017.

Alicia Jaramillo-Underwood, Daniel Impoinvil, Alice Sutcliff, Karen E S Hamre, Vena Joseph, Lotus van den Hoogen, Jean Frantz Lemoine, Ruth A Ashton, Michelle A Chang, Alexandre Existe and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Spatial, environmental, and individual associations withFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alicia Jaramillo-UnderwoodDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Daniel ImpoinvilDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Alice SutcliffDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Karen E S HamreDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Vena JosephCenter for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Lotus van den HoogenDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Jean Frantz LemoineProgramme National de Contrôle de la Malaria, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Ruth A AshtonCenter for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Michelle A ChangDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Alexandre ExisteLaboratorie National de Santé Publique, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Jacques BoncyLaboratorie National de Santé Publique, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Chris DrakeleyDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Gillian StresmanDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Thomas DruetzCenter for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.ORCID 0000-0002-9234-4286
Thomas EiseleCenter for Applied Malaria Research and Evaluation, Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Eric RogierDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-7375-8304

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Serological data can provide estimates of human exposure to both malaria vector and parasite based on antibody responses. A multiplex bead-based assay was developed to simultaneously detect IgG to Anopheles albimanus salivary gland extract (SGE) and 23 Plasmodium falciparum antigens among 4185 participants enrolled in Artibonite department, Haiti in 2017. Logistic regression adjusted for participant- and site-level covariates and found children under 5 years and 6-15 years old had 3.7- and 5.4-fold increase in odds, respectively, of high anti-SGE IgG compared to participants >15 years. Seropositivity to P. falciparum CSP, Rh2_2030, and SEA-1 antigens was significantly associated with high IgG response against SGE, and participant enrolment at elevations under 200 m was associated with higher anti-SGE IgG levels. The ability to approximate population exposure to malaria vectors through SGE serology data is very dependent by age categories, and SGE antigens can be easily integrated into a multiplex serological assay.

Indexed as

AnophelesMalariaMalaria, FalciparumAnimalsAntibody FormationAntigensChildChild, PreschoolHaitiHumansImmunoglobulin GMosquito VectorsPlasmodium falciparumSalivary GlandsAntigensImmunoglobulin GAnopheles albimanusimmunoglobulin Gmosquito salivamultiplex serologyPlasmodium falciparum

Identifiers

PMID35711005
PMCPMC10982684

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.