ArticleScientific reports2022
Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.Lab animal · 2026Review
- Disruption of carotenoid metabolism in cavefish via loss of beta-carotene oxygenase 2a.Current biology : CB · 2026Article
- Widespread loss of sleep in independently evolved populations of wild-caught cavefish.iScience · 2025Article
- Article
- Divergent 3D genome organization in livers of cave and surface morphs ofbioRxiv : the preprint server for biology · 2025Article
- Conditions for establishing fin primary cell cultures in a wide range of ray-finned fishes.In vitro cellular & developmental biology. Animal · 2025Article
- RNA-seq analysis of blood from cave- and surface-dwellingFrontiers in physiology · 2025Article
- 3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Blind fish have cells that see light.Proceedings. Biological sciences · 2023Article
- The cavefish Astyanax mexicanus.Nature methods · 2023Article
- Establishment, Long-Term Maintenance, and Characterization of Primary Liver Cells from Astyanax mexicanus.Current protocols · 2023Article
- Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Cell lines have become an integral resource and tool for conducting biological experiments ever since the Hela cell line was first developed (Scherer et al. in J Exp Med 97:695-710, 1953). They not only allow detailed investigation of molecular pathways but are faster and more cost-effective than most in vivo approaches. The last decade saw many emerging model systems strengthening basic science research. However, lack of genetic and molecular tools in these newer systems pose many obstacles. Astyanax mexicanus is proving to be an interesting new model system for understanding metabolic adaptation. To further enhance the utility of this system, we developed liver-derived cell lines from both surface-dwelling and cave-dwelling morphotypes. In this study, we provide detailed methodology of the derivation process along with comprehensive biochemical and molecular characterization of the cell lines, which reflect key metabolic traits of cavefish adaptation. We anticipate these cell lines to become a useful resource for the Astyanax community as well as researchers investigating fish biology, comparative physiology, and metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.