ArticleScientific reports2022
Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
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- Ammonia Exposure Elevated 5-HT Expression, Reprogrammed Transcriptome and Microbiota Community in Yellow Catfish (Microorganisms · 2026Article
- Single-cell atlas ofZoological research · 2026Article
- Resolving the cellular profile of germinal center-analogous microstructures in zebrafish.Frontiers in immunology · 2026Article
- Specialized gas-exchange endothelium of the zebrafish gill.bioRxiv : the preprint server for biology · 2025Article
- Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill.The Journal of physiology · 2025Article
- Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish.Genome biology · 2025Article
- Genetic map of the carotid body stem cell niche with focus on the OScientific reports · 2025Article
- Thymflammation: The Role of a Constitutively Active Inflammatory Network and "Ectopic" Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond.Immunological reviews · 2025Review
- Oxygen chemoreceptor inhibition by dopamine DThe Journal of physiology · 2025Article
- Dopamine inhibits gill OThe Journal of physiology · 2025Article
- Hypoxia tolerance and physiological coping strategies in fat greenling (Hexagrammos otakii).Fish physiology and biochemistry · 2025Article
- Evolution of Key Oxygen-Sensing Genes Is Associated with Hypoxia Tolerance in Fishes.Genome biology and evolution · 2024Article
- Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Hif-2α programs oxygen chemosensitivity in chromaffin cells.The Journal of clinical investigation · 2024Article
- A review on current advancement in zebrafish models to study chronic inflammatory diseases and their therapeutic targets.Heliyon · 2024Review
- Identification of signalling pathways involved in gill regeneration in zebrafish.The Journal of experimental biology · 2024Article
- Diverse responses of hypoxia-inducible factor alpha mRNA abundance in fish exposed to low oxygen: the importance of reporting methods.Frontiers in physiology · 2024Review
- Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data ofBiology · 2023Review
- Article
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6 authors at 3 institutions in 1 country.
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Abstract
The fish gill is a multifunctional organ involved in numerous physiological processes, such as gas exchange and sensing of hypoxia by respiratory chemoreceptors, called neuroepithelial cells (NECs). Many studies have focused on zebrafish (Danio rerio) to investigate the structure, function and development of the gills, yet the transcriptomic profile of most gill cells remains obscure. We present the results of a comprehensive transcriptomic analysis of the gills of zebrafish using single-cell RNA sequencing (scRNA-seq). Gill cells from ETvmat2:EGFP zebrafish were individually labelled before scRNA-seq library construction using 10× Genomics Chromium technology. 12,819 cells were sequenced with an average depth of over 27,000 reads per cell. We identified a median of 485 genes per cell and 16 cell clusters, including NECs, neurons, pavement cells, endothelial cells and mitochondrion-rich cells. The identity of NECs was confirmed by expression of slc18a2, encoding the vesicular monoamine transporter, Vmat2. Highly differentially-expressed genes in NECs included tph1a, encoding tryptophan hydroxylase, sv2 (synaptic vesicle protein), and proteins implicated in O
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