ArticleCommunications biology2022
Capturing additional genetic risk from family history for improved polygenic risk prediction.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study.Molecular autism · 2026Article
- Evaluation of the genome-informed risk assessment (GIRA) approach from eMERGE in an independent health system.medRxiv : the preprint server for health sciences · 2026Article
- Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.BMC medicine · 2026Article
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Genetic and Molecular Determinants of Familial Transmission of Skeletal Malocclusions.Orthodontics & craniofacial research · 2025Review
- Within-family analysis of PRSJournal, genetic engineering & biotechnology · 2025Article
- Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses.JAMA oncology · 2025Article
- Estimating disorder probability based on polygenic prediction using the BPC approach.Nature communications · 2025Article
- Effects of polygenic risk score and sodium and potassium intake on hypertension in Asians: A nationwide prospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association of Family History and Polygenic Risk Score With Longitudinal Prognosis in Parkinson Disease.Neurology. Genetics · 2024Article
- Development of risk prediction models for depression combining genetic and early life risk factors.Frontiers in neuroscience · 2023Article
- The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).Frontiers in epidemiology · 2023Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle factors, as well as a common genetic predisposition. We developed a latent factor model to quantify trait heritability in excess of that captured by a common variant-based polygenic risk score, but inferable from family history. For 941 children in the Avon Longitudinal Study of Parents and Children cohort, a joint predictor combining a polygenic risk score for height and mid-parental height was able to explain
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