Evidence map›Paper›PMID 35710623›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism.

Louis John Kolling, Roberta Tatti, Troy Lowry, Ashley M Loeven, James M Fadool, Debra Ann Fadool

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Louis John KollingInstitute of Molecular Biophysics, The Florida State University, Tallahassee, Florida 32306.
Roberta TattiDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306.
Troy LowryDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306.
Ashley M LoevenDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306.
James M FadoolDepartment of Biological Science, The Florida State University, Tallahassee, Florida 32306.
Debra Ann FadoolInstitute of Molecular Biophysics, The Florida State University, Tallahassee, Florida 32306 dfadool@bio.fsu.edu.ORCID https://orcid.org/0000-0002-0546-3720
Florida State University · US

Funding

Chemosensory Training Program (CTP)T32DC000044 · NIDCD · FLORIDA STATE UNIVERSITY · PI DEBRA Ann FADOOL · 1995 to 2026
$5.3M
Probing the link between sensory systems and metabolism to prevent obesityR01DK133464 · NIDDK · FLORIDA STATE UNIVERSITY · PI DEBRA Ann FADOOL · 2023 to 2026
$1.7M
Mechanisms of photoreceptor specification and morphogenesisR01EY030633 · NEI · FLORIDA STATE UNIVERSITY · PI FADOOL, JAMES M · 2020 to 2023
$1.4M
Regulation of Metabolism and the Impact of Obesity for Olfactory SignalingR01DC013080 · NIDCD · FLORIDA STATE UNIVERSITY · PI FADOOL, DEBRA ANN · 2014 to 2017
$1.2M
NEI NIH HHS R01 EY030633NIDCD NIH HHS R01 DC013080NIDCD NIH HHS T32 DC000044NIDDK NIH HHS R01 DK133464
6 · The paper itself

Abstract

Metabolic state can alter olfactory sensitivity, but it is unknown whether the activity of the olfactory bulb (OB) may fine tune metabolic homeostasis. Our objective was to use CRISPR gene editing in male and female mice to enhance the excitability of mitral/tufted projection neurons (M/TCs) of the OB to test for improved metabolic health.

Indexed as

Diabetes Mellitus, Type 2AnimalsBody WeightDiet, High-FatFemaleHumansMaleMiceMice, Inbred C57BLNeuronsObesityOlfactory BulbCRISPRKv1.3obesityolfactionolfactory bulbpotassium channel

Identifiers

PMID35710623
PMCPMC9337614
OpenAlexW4282973403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.