ArticleJournal of animal science and biotechnology2022
Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets.
Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Soybean oil and leucine in late gestation and lactation improve maternal and offspring lipid metabolism and insulin sensitivity: insights from pig model.Frontiers in veterinary science · 2026Article
- The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling.International journal of biological sciences · 2026Review
- Increased maternal valine intake in low-protein diets accelerates growth performance of suckling piglets by improving mammary gland-fetal intestinal metabolism.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Oral Administration of L-Arginine Improves the Growth and Survival of Sow-Reared Intrauterine Growth-Restricted Piglets.Animals : an open access journal from MDPI · 2025Article
- Metabolomic and lipidomic insights into the impact ofComputational and structural biotechnology journal · 2025Article
- Supplementing Monosodium Glutamate in Sow Diets Enhances Reproductive Performance in Lactating Sows and Improves the Growth of Suckling Piglets.Animals : an open access journal from MDPI · 2024Article
- Abomasal infusion of branched-chain amino acids or branched-chain keto-acids alter lactation performance and liver triglycerides in fresh cows.Journal of animal science and biotechnology · 2024Article
- Effect of various levels of standardized ileal digestible branched-chain amino acids on lactating sow and litter performance.Translational animal science · 2024Article
- Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring.Journal of animal science and biotechnology · 2023Article
- Enhancing Milk Production by Nutrient Supplements: Strategies and Regulatory Pathways.Animals : an open access journal from MDPI · 2023Review
- Serum metabolomic characterization in pigs in relation to birth weight category and neonatal nutrition.Journal of animal science · 2023Article
- Branched-chain amino acids regulate intracellular protein turnover in porcine mammary epithelial cells.Amino acids · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundUnder current dietary regimens, milk production by lactating sows is insufficient to sustain the maximal growth of their piglets. As precursors of glutamate and glutamine as well as substrates and activators of protein synthesis, branched-chain amino acids (BCAAs) have great potential for enhancing milk production by sows.
methodsThirty multiparous sows were assigned randomly into one of three groups: control (a corn- and soybean meal-based diet), the basal diet + 1.535% BCAAs; and the basal diet + 3.07% BCAAs. The ratio (g/g) among the supplemental L-isoleucine, L-leucine and L-valine was 1.00:2.56:1.23. Diets were made isonitrogenous by the addition of appropriate amounts of L-alanine. Lactating sows had free access to drinking water and their respective diets. The number of live-born piglets was standardized to 9 per sow at d 0 of lactation (the day of parturition). On d 3, 15 and 29 of lactation, body weights and milk consumption of piglets were measured, and blood samples were obtained from sows and piglets 2 h and 1 h after feeding and nursing, respectively.
resultsFeed intake did not differ among the three groups of sows. Concentrations of asparagine, glutamate, glutamine, citrulline, arginine, proline, BCAAs, and many other amino acids were greater (P < 0.05) in the plasma of BCAA-supplemented sows and their piglets than those in the control group. Compared with the control, dietary supplementation with 1.535% and 3.07% BCAAs increased (P < 0.05) concentrations of free and protein-bound BCAAs, glutamate plus glutamine, aspartate plus asparagine, and many other amino acids in milk; milk production by 14% and 21%, respectively; daily weight gains of piglets by 19% and 28%, respectively, while reducing preweaning mortality rates by 50% and 70%, respectively.
conclusionDietary supplementation with up to 3.07% BCAAs enhanced milk production by lactating sows, and the growth and survival of their piglets.
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