ReviewBiotechnology for biofuels and bioproducts2022
Recent advances in microbial ε-poly-L-lysine fermentation and its diverse applications.
Review in Biotechnology for biofuels and bioproducts, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synergistic bactericidal mechanism of carvacrol and ε-polylysine againstRSC advances · 2026Article
- Article
- Antimicrobial activity of silver free powder coatings based on biocomponents.Scientific reports · 2025Article
- Efficacy of Toothpaste Containing Polylysine and Funme Peptide on Oral Microbiome and Oral Health.International dental journal · 2025Article
- The in vitro assessment of resin coating materials containing calcium phosphate, bioactive glass, and polylysine for glass ionomer cement restorations.Biomaterial investigations in dentistry · 2025Article
- Synergistic Polymer Coatings with Antibacterial and Antiviral Properties for Healthcare Applications.ACS omega · 2024Article
- Activity of Epsilon-poly-L-lysine against Multidrug-ResistantBiomedicines · 2024Article
- Article
- Graphene oxide/ε-poly-L-lysine self-assembled functionalized coatings improve the biocompatibility and antibacterial properties of titanium implants.Frontiers in bioengineering and biotechnology · 2024Article
- OptimizingFrontiers in microbiology · 2024Review
- Metabolic perturbation ofFrontiers in microbiology · 2024Article
- Article
- Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus.Microbial cell factories · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The naturally occurring homo-polyamide biopolymer, ε-poly-L-lysine (ε-PL) consists of 25-35 L-lysine residues with amide linkages between α-carboxyl groups and ε-amino groups. ɛ-PL exhibits several useful properties because of its unusual structure, such as biodegradability, water solubility, no human toxicity, and broad-spectrum antibacterial activities; it is widely applied in the fields of food, medicine, clinical chemistry and electronics. However, current industrial production of ε-PL is only performed in a few countries. Based on an analysis of the physiological characteristics of ε-PL fermentation, current advances that enhance ε-PL fermentation, from strain improvement to product isolation are systematically reviewed, focusing on: (1) elucidating the metabolic pathway and regulatory mechanism of ε-PL synthesis; (2) enhancing biosynthetic performance through mutagenesis, fermentation optimization and metabolic engineering; and (3) understanding and improving the biological activity and functional properties of ε-PL. Finally, perspectives on engineering and exploiting ε-PL as a source material for the production of various advanced materials are also discussed, providing scientific guidelines for researchers to further improve the ε-PL fermentation process.
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Registered trials
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