Evidence map›Paper›PMID 35710406›Full record

ArticleBMC nephrology2022

Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1.

Sudha Priya Soundara Pandi, Michael J Shattock, Bruce M Hendry, Claire C Sharpe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sudha Priya Soundara PandiDepartment of Inflammation Biology, King's College London, Denmark Hill Campus, James Black Centre, London, SE5 9NU, UK.
Michael J ShattockSchool of Cardiovascular Medicine and Sciences, King's College London, London, UK.
Bruce M HendryDepartment of Inflammation Biology, King's College London, Denmark Hill Campus, James Black Centre, London, SE5 9NU, UK.
Claire C SharpeDepartment of Inflammation Biology, King's College London, Denmark Hill Campus, James Black Centre, London, SE5 9NU, UK. Claire.sharpe@kcl.ac.uk.
King's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT-type calcium channels (TTCC) are low voltage activated channels that are widely expressed in the heart, smooth muscle and neurons. They are known to impact on cell cycle progression in cancer and smooth muscle cells and more recently, have been implicated in rat and human mesangial cell proliferation. The aim of this study was to investigate the roles of the different isoforms of TTCC in mouse mesangial cells to establish which may be the best therapeutic target for treating mesangioproliferative kidney diseases. 

methodsIn this study, we generated single and double knockout (SKO and DKO) clones of the TTCC isoforms Ca

resultsWe demonstrate a complete loss of ERK1/2 phosphorylation in response to multiple stimuli (serum, PDGF, TGF-β1) in Ca

conclusionThis study confirms that TTCC are expressed in mouse mesangial cells and that they play a role in cell proliferation. Whereas the Ca

Indexed as

Calcium Channels, T-TypeMesangial CellsAnimalsHumansMibefradilMicePhosphorylationRatsTransforming Growth Factor beta1Calcium Channels, T-TypeMibefradilTransforming Growth Factor beta1Calcium channelsCRISPR-cas9ERK1/2GlomerulonephritisMesangial cell

Identifiers

PMID35710406
PMCPMC9205043
OpenAlexW4283023870

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.