Evidence map›Paper›PMID 35710394›Full record

ArticleTrials2022

The clinical effectiveness and cost-effectiveness of a 'stepping into day treatment' approach versus inpatient treatment as usual for anorexia nervosa in adult specialist eating disorder services (DAISIES trial): a study protocol of a randomised controlled multi-centre open-label parallel group non-inferiority trial.

Madeleine Irish, Bethan Dalton, Laura Potts, Catherine McCombie, James Shearer, Katie Au, Nikola Kern, Sam Clark-Stone, Frances Connan, A Louise Johnston and 15 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 1 country.

Madeleine Irish *Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Bethan Dalton *Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-0898-1926
Laura PottsDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Catherine McCombieDepartment of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
James ShearerDepartment of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Katie AuSouth London and Maudsley NHS Foundation Trust, London, UK.
Nikola KernSouth London and Maudsley NHS Foundation Trust, London, UK.
Sam Clark-StoneGloucestershire Health and Care NHS Foundation Trust, Gloucester, UK.
Frances ConnanCentral and North West London NHS Foundation Trust, London, UK.
A Louise JohnstonNHS Grampian, Aberdeen, UK.
Stanimira LazarovaSouth West London and St George's Mental Health NHS Trust, London, UK.
Shiona MacdonaldNHS Dumfries and Galloway, Dumfries, UK.
Ciarán NewellDorset HealthCare University NHS Foundation Trust, Poole, UK.
Tayeem PathanSurrey and Borders Partnership NHS Foundation Trust, Leatherhead, UK.
Jackie WalesLeicestershire Adult Eating Disorders Service, Leicestershire Partnership NHS Trust, Bennion Centre, Glenfield Hospital, Leicester, UK.
Rebecca CashmoreLeicestershire Adult Eating Disorders Service, Leicestershire Partnership NHS Trust, Bennion Centre, Glenfield Hospital, Leicester, UK.
Sandra MarshallLeicestershire Adult Eating Disorders Service, Leicestershire Partnership NHS Trust, Bennion Centre, Glenfield Hospital, Leicester, UK.
Jon ArcelusInstitute of Mental Health, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham, NG7 2TU, UK.
Paul RobinsonDivision of Medicine, University College London, 5 University Street, London, WC1E, 6JF, UK.
Hubertus HimmerichSection of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Vanessa C LawrenceDepartment of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Janet TreasureSection of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Sarah ByfordDepartment of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Sabine LandauDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
Ulrike SchmidtSection of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK. ulrike.schmidt@kcl.ac.uk.
King's College London · GBGlenfield Hospital · GBSouth London and Maudsley NHS Foundation Trust · GBCentral and North West London NHS Foundation Trust · GBDorset HealthCare University NHS Foundation Trust · GBGloucestershire Health and Care NHS Foundation Trust · GBNHS Dumfries and Galloway · GBNHS Grampian · GBSouth West London and St George's Mental Health NHS Trust · GBSurrey and Borders Partnership NHS Foundation Trust · GBUniversity College London · GBUniversity of Nottingham · GB

Funding

Health Technology Assessment Programme 17/123/03
6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) is a serious and disabling mental disorder with a high disease burden. In a proportion of cases, intensive hospital-based treatments, i.e. inpatient or day patient treatment, are required, with day patient treatment often being used as a 'step-down' treatment after a period of inpatient treatment. Demand for such treatment approaches has seen a sharp rise. Despite this, the relative merits of these approaches for patients, their families, and the NHS and wider society are relatively unknown. This paper describes the rationale for, and protocol of, a two-arm multi-centre open-label parallel group non-inferiority randomised controlled trial, evaluating the effectiveness and cost-effectiveness of these two intensive treatments for adults with severe AN: inpatient treatment as usual and a stepped care day patient approach (the combination of day patient treatment with the option of initial inpatient treatment for medical stabilisation). The main aim of this trial is to establish whether, in adults with severe AN, a stepped care day patient approach is non-inferior to inpatient treatment as usual in relation to improving body mass index (BMI) at 12 months post-randomisation.

methods386 patients with a Diagnostic and Statistical Manual 5th edition diagnosis of severe AN or related disorder, with a BMI of ≤16 kg/m DISCUSSION: The results of this study will provide a rigorous evaluation of two intensive treatment approaches which will inform future national and international treatment guidelines and service provision.

trial registrationISRCTN ISRCTN10166784 . Registered 28 February 2020. ISRCTN is a primary registry of the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) network and includes all items from the WHO Trial Registration Data Set.

Indexed as

Anorexia NervosaFeeding and Eating DisordersAdultCost-Benefit AnalysisEquivalence Trials as TopicHumansInpatientsMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeAnorexia nervosaDay patient treatmentInpatient treatmentIntensive treatmentPartial hospitalisationStepped care

Identifiers

PMID35710394
PMCPMC9201798
OpenAlexW4283033175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.