ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
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- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking.Quantitative imaging in medicine and surgery · 2025Article
- Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults.Journal of psychiatric research · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- Aberrant regional homogeneity in multiple frequency bands in patients with alcohol use disorder.Frontiers in psychiatry · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Hypothalamic connectivities and self-evaluated aggression in young adults.bioRxiv : the preprint server for biology · 2024Article
- Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study.Quantitative imaging in medicine and surgery · 2024Article
- Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory.Quantitative imaging in medicine and surgery · 2024Article
- Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking.Brain sciences · 2024Article
- Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers.Neuroimage. Reports · 2024Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers.Addiction neuroscience · 2023Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
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5 authors at 2 institutions in 2 countries.
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Abstract
backgroundAlcohol misuse is associated with externalizing behaviors, including rule breaking. Studies have implicated altered reward processing in externalizing behaviors and alcohol misuse. Here, we investigated whether reward or punishment reactivity more significantly influenced alcohol use severity and rule-breaking behavior in young adult drinkers.
methodsWe curated data from the Human Connectome Project and identified 181 binge (132 men) and 288 nonbinge (97 men) drinkers performing a gambling task during brain imaging. Alcohol use severity was quantified by the first principal component of principal-component analysis of all drinking measures. We analyzed the imaging data using published routines and evaluated the results at a corrected threshold. We examined the interrelationship between imaging and clinical metrics with mediation and path analyses.
resultsCompared with nonbingers, bingers showed more severe rule-breaking behavior and responded significantly faster during post-loss than during post-win trials. Compared with nonbingers, bingers demonstrated greater inferior/middle frontal gyrus and cerebellum activations in loss-predominating blocks but no differences in regional responses to win-predominating blocks, relative to an interblock baseline. The right caudate body showed loss reactivity that was positively correlated with the rule-breaking score. No regional responses to wins were significantly correlated with the rule-breaking score. Mediation and path analyses demonstrated significant models with inferior/middle frontal gyrus and caudate reactivity to loss interrelating rule breaking and alcohol use severity.
conclusionsPunishment rather than reward reactivity was associated with alcohol use severity and rule breaking in young adults. The findings highlight the roles of negative emotions in psychological models of externalizing behaviors and alcohol misuse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.