ArticleCerebral cortex (New York, N.Y. : 1991)2023
Dissociating the functional roles of arcuate fasciculus subtracts in speech production.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Double dissociation between conduction aphasia and conduction agraphia supports a ventro-dorsal partition of the left arcuate fasciculus.Journal of neuropsychology · 2026Article
- Dynamic Causal Tractography Analysis of Auditory Descriptive Naming: An Intracranial Study of 106 Patients.NeuroImage · 2025Article
- Long arcuate fascicle in wild and captive chimpanzees as a potential structural precursor of the language network.Nature communications · 2025Article
- Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus.Communications biology · 2024Article
- On the role of the arcuate fasciculus in word production and repetition: a reply to Van den Hoven et al. (2024).Brain structure & function · 2024Article
- Wernicke's functional neuroanatomy model of language turns 150: what became of its psychological reflex arcs?Brain structure & function · 2024Review
- Anatomical considerations in selective amygdalohippocampectomy techniques for refractory temporal lobe epilepsy: a cadaveric study with emphasis on white matter tract anatomy.Surgical and radiologic anatomy : SRA · 2024Article
- Time to bury the chisel: a continuous dorsal association tract system.Brain structure & function · 2024Article
- Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study.Alzheimer's research & therapy · 2024Article
- Embracing digital innovation in neuroscience: 2023 in review at NEUROCCINO.Brain structure & function · 2024Review
- Decoding kinematic information from beta-band motor rhythms of speech motor cortex: a methodological/analytic approach using concurrent speech movement tracking and magnetoencephalography.Frontiers in human neuroscience · 2024Article
- The arcuate fasciculus: Combining structure and function into surgical considerations.Brain and behavior · 2023Review
- Exploring the arcuate fasciculus from a clinical perspective.Frontiers in neuroscience · 2023Review
- Comparing human and chimpanzee temporal lobe neuroanatomy reveals modifications to human language hubs beyond the frontotemporal arcuate fasciculus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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6 authors.
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Abstract
Recent tractography and microdissection studies have shown that the left arcuate fasciculus (AF)-a fiber tract thought to be crucial for speech production-consists of a minimum of 2 subtracts directly connecting the temporal and frontal cortex. These subtracts link the posterior superior temporal gyrus (STG) and middle temporal gyrus (MTG) to the inferior frontal gyrus. Although they have been hypothesized to mediate different functions in speech production, direct evidence for this hypothesis is lacking. To functionally segregate the 2 AF segments, we combined functional magnetic resonance imaging with diffusion-weighted imaging and probabilistic tractography using 2 prototypical speech production tasks, namely spoken pseudoword repetition (tapping sublexical phonological mapping) and verb generation (tapping lexical-semantic mapping). We observed that the repetition of spoken pseudowords is mediated by the subtract of STG, while generating an appropriate verb to a spoken noun is mediated by the subtract of MTG. Our findings provide strong evidence for a functional dissociation between the AF subtracts, namely a sublexical phonological mapping by the STG subtract and a lexical-semantic mapping by the MTG subtract. Our results contribute to the unraveling of a century-old controversy concerning the functional role in speech production of a major fiber tract involved in language.
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