Evidence map›Paper›PMID 35709709›Full record

ArticleBlood cancer discovery2022

Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia.

Kyle A Romine, Peter van Galen

Abstract readComment
In one paragraph

Article in Blood cancer discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Kyle A RomineDepartment of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0003-3757-7690
Peter van GalenDivision of Hematology, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-0735-1570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.

Indexed as

Leukemia, Myeloid, AcuteMyelodysplastic SyndromesNeoplasms, Second PrimaryClonal EvolutionClone CellsHumans

Identifiers

PMID35709709
PMCPMC9338726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.