Evidence map›Paper›PMID 35709685›Full record

ArticleDrug metabolism and pharmacokinetics2022

Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers.

Washim Khan, Yan-Hong Wang, Narayan D Chaurasiya, Np Dhammika Nanayakkara, Hm Bandara Herath, Kerri A Harrison, Gray Dale, Donald A Stanford, Eric P Dahl, James D McChesney and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and pharmacokinetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Washim KhanNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Yan-Hong WangNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Narayan D ChaurasiyaDepartment of Infectious Diseases, Division of Drug Discovery, Southern Research Institute, Birmingham, AL, 35205, USA.
Np Dhammika NanayakkaraNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Hm Bandara HerathNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Kerri A HarrisonNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Gray DaleNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Donald A StanfordNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Eric P DahlNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
James D McChesneyIronstone Separations, Inc., Etta, MS, 38627, USA.
Waseem GulElSohly Laboratories, Inc., Oxford, MS, 38655, USA.
Mahmoud A ElSohlyNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA; Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA; ElSohly Laboratories, Inc., Oxford, MS, 38655, USA.
Shabana I KhanNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
Pius S FasinuDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Ikhlas A KhanNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA; Departments of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Babu L TekwaniDepartment of Infectious Diseases, Division of Drug Discovery, Southern Research Institute, Birmingham, AL, 35205, USA. Electronic address: btekwani@southernresearch.org.
Larry A WalkerNational Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA. Electronic address: lwalker@olemiss.edu.
University of Mississippi · USSouthern Research Institute · USElSohly Laboratories (United States) · USUniversity of Alabama at Birmingham · US

Funding

Primaquine metabolism and treatment of P. vivax in MadagascarR01AI148469 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI WILLIAMS, SCOTT MATTHEW, ZIMMERMAN, PETER A. · 2020 to 2023
$2.6M
NIAID NIH HHS R01 AI148469
6 · The paper itself

Abstract

Primaquine (PQ) is a racemic drug used in treatment of malaria for six decades. Recent studies suggest that the two enantiomers of PQ are differentially metabolized in animals, and this results in different pharmacological and toxicological profiles. The current study characterizes the pharmacokinetic (PK) properties, metabolism and tolerability of the individual enantiomers of PQ in healthy human volunteers with normal glucose-6-phosphate dehydrogenase (G6PD) activity. Two cohorts (at two dose levels), each with 18 subjects, participated in three study arms in a crossover fashion: a single dose of the (-)-R enantiomer (RPQ), a single dose of the (+)-S enantiomer (SPQ), and a single dose of racemic PQ (RSPQ). PQ and its key metabolites carboxyprimaquine (cPQ) and PQ-N-carbamoyl glucuronide (PQ-N-CG) were analyzed. Clear differences were observed in PK and metabolism of the two enantiomers. Relative PQ exposure was higher with SPQ as compared to RPQ. PQ maximum plasma concentration (C

Indexed as

AntimalarialsPrimaquineAnimalsHealthy VolunteersHumansStereoisomerismAntimalarialsPrimaquineCarboxyprimaquineEnantiomersPharmacokineticsPrimaquinePrimaquine-N-Carbamoyl-glucuronideRacemateUHPLC-MS/MS

Identifiers

PMID35709685
PMCPMC9789533
OpenAlexW4225271960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.