Evidence map›Paper›PMID 35709481›Full record

ArticleInternational journal of radiation biology2023

Microdosimetric and radiobiological effects of gold nanoparticles at therapeutic radiation energies.

Tara M Gray, Shaquan David, Nema Bassiri, Devanshi Yogeshkumar Patel, Neil Kirby, Kathryn M Mayer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tara M GrayDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX, USA.
Shaquan DavidDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX, USA.
Nema BassiriDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Devanshi Yogeshkumar PatelDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX, USA.
Neil KirbyDepartment of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Kathryn M MayerDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-9533-8527
The University of Texas at San Antonio · USThe University of Texas Health Science Center at San Antonio · US

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
NIGMS NIH HHS R25 GM060655
6 · The paper itself

Abstract

purposeThe purpose of this study was to quantify the microscopic dose distribution surrounding gold nanoparticles (GNPs) irradiated at therapeutic energies and to measure the changes in cell survival in vitro caused by this dose enhancement.

methodsThe dose distributions from secondary electrons surrounding a single gold nanosphere and single gold nanocube of equal volume were both simulated using MCNP6. Dose enhancement factors (DEFs) in the 1 μm

resultsIt was observed that the dose from electrons surrounding the gold nanocube surpasses that of a gold nanosphere up to a distance of 1.1 μm by 18.5% for the 18 MV energy spectrum and by 23.1% for the 6 MV spectrum. DEFs ranging from ∼2 to 8 were found, with the maximum DEF resulting from the case of the gold nanocube irradiated at 6 MV energy. Experimentally, for irradiation at 18 MV, incubating cells with 6 nM (0.10% gold by mass) GNPs produces an average 6.7% decrease in cell survival, and incubating cells with 9 nM (0.15% gold by mass) GNPs produces an average 14.6% decrease in cell survival, as compared to cells incubated and irradiated without GNPs.

conclusionWe have successfully demonstrated the potential radiation dose enhancing effects in vitro and microdosimetrically from gold nanoparticles.

Indexed as

GoldMetal NanoparticlesElectronsMonte Carlo MethodGolddose enhancement factorGold nanoparticlesmicrodosimetryMonte Carlo simulationsradiation therapy

Identifiers

PMID35709481
PMCPMC10089366
OpenAlexW4283026249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.