ArticleScience (New York, N.Y.)2022
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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72citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Proteins targeting ischaemic-reperfusion injury and repair after myocardial infarction: a systematic literature review.Cardiovascular research · 2026Pooled it
- Effects of 12-week exercise on Meteorin-like levels, inflammation, and functional capacity in older adults: Korean national aging project randomized controlled study.European geriatric medicine · 2025Trial
- Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.Frontiers in endocrinology · 2024Trial
- Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation.Circulation · 2026Article
- Meteorin-like regulates cardiac repair via macrophage modulation following myocardial infarction.Basic research in cardiology · 2026Article
- Molecular Mechanisms Governing Vascular Function in Heart Failure.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Metrnl in mitigating radiation enteritisActa pharmaceutica Sinica. B · 2026Article
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- Phosphoproteomics in Vascular Biology and Disease: Illuminating Signaling in the Vessel.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.Nature communications · 2026Article
- Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential.Archives of pharmacal research · 2026Review
- Single-cell transcriptomics and machine learning identify RNF144B and C5AR1 as immune-related molecular signatures and therapeutic targets in myocardial infarction.Genes & genomics · 2026Article
- Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis.Science advances · 2026Article
- Metrnl in diabetes and its complications: divergent evidence and translational prospects.Journal of translational medicine · 2026Review
- Association between serum meteorin-like protein and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus: a cross-sectional study.Endocrine connections · 2026Article
- Metrnl in health and disease: tissue-specific actions and signaling networks.Apoptosis : an international journal on programmed cell death · 2026Review
- KIT supports small intestinal tuft cell hyperplasia.Science advances · 2026Article
- Metrnl/Meteorin-like/IL-41 Alleviates Rheumatoid Arthritis Via PPARγ-Mediated Suppression of Inflammation, Angiogenesis, and Bone Destruction.Inflammation · 2026Article
- Metrnl and macrophage polarization: role in skeletal muscle homeostasis and therapeutic potential.Frontiers in immunology · 2026Review
- Skeletal muscle-heart crosstalk in chronic kidney disease: hierarchical signaling networks underlying myocardial metabolic reprogramming and fibrotic remodeling.Frontiers in physiology · 2026Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 6 institutions in 3 countries.
Marc R RebollDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-4135-8434
Stefanie KledeDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.
Manuel H TaftInstitute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-5853-8629
Chen-Leng CaiDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Loren J FieldKrannert Cardiovascular Research Center and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Kory J LavineCenter for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1948-9945
Andrew L KoenigCenter for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4384-1267
Jenni FleischauerInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Johann MeyerInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-9521-1334
Axel SchambachInstitute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Hans W NiessenDepartment of Pathology and Department of Cardiac Surgery, Institute for Cardiovascular Research, Amsterdam University Medical Center, 1007 MB Amsterdam, Netherlands.ORCID 0000-0001-9404-9822
Maike KosankeResearch Core Unit Genomics, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-5910-2007
Joop van den HeuvelTechnology Platform Recombinant Protein Expression, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0001-5085-4010
Andreas PichCore Unit Proteomics and Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9341-117X
Xuekun WuDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-5429-3126
Linqun ZhengDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.
Yong WangDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-4905-4195
Mortimer Korf-KlingebielDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.
Felix PoltenDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-1076-5272
Kai C WollertDivision of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-4890-4450
Medizinische Hochschule Hannover · DEWashington University in St. Louis · USAmsterdam University Medical Centers · NLHelmholtz Centre for Infection Research · DEIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine
Funding
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MPediatric Cardiovascular and Pulmonary Research Training Program.T32HL125241 · NHLBI · WASHINGTON UNIVERSITY · PI Juliane Bubeck Wardenburg, Kory J. Lavine · 2015 to 2026
$4.1MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MSequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following InjuryR01HL155218 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIELD, LOREN J · 2021 to 2024
$2.0MDeciphering the mechanisms of c-kit+ cells in heart repairR01HL137036 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI SHOU, WEINIAN · 2018 to 2021
$1.6MCardiomyocyte cell cycle activity in injured heartsR01HL132927 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIELD, LOREN J · 2017 to 2020
$1.6MNHLBI NIH HHS R01 HL132927NHLBI NIH HHS R01 HL137036NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R01 HL155218NHLBI NIH HHS R35 HL161185NHLBI NIH HHS T32 HL125241
Abstract
Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone.
Indexed as
AdipokinesCytokinesMyocardial InfarctionNeovascularization, PhysiologicNerve Growth FactorsProto-Oncogene Proteins c-kitAnimalsCells, CulturedEndothelial CellsHeart FailureLigandsMacrophagesMiceMice, Mutant StrainsAdipokinescometin protein, mouseCytokinesLigandsMetrnl protein, humanNerve Growth FactorsProto-Oncogene Proteins c-kit
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.