Evidence map›Paper›PMID 35708820›Full record

ReviewCurrent hypertension reports2022

Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.

John S Clemmer, Tariq Shafi, Yoshitsugu Obi

Open access · greenAbstract readReview
In one paragraph

Review in Current hypertension reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Observational
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  4. Article
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  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

John S ClemmerDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Tariq ShafiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Yoshitsugu ObiDivision of Nephrology, University of Mississippi Medical Center, 2500 North State Street, Suite L-504, Jackson, MS, 39216, USA. yobi@umc.edu.ORCID 0000-0001-7032-4383
State Street (United States) · USJackson Memorial Hospital · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
Improving Hypertension Treatment in African Americans Using Computational Modeling and Predictive AnalyticsR00MD014738 · NIMHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI CLEMMER, JOHN S · 2022 to 2024
$747k
NIGMS NIH HHS U54 GM115428NIMHD NIH HHS R00 MD014738
6 · The paper itself

Abstract

purpose of reviewIn this article, we summarize recent advances in understanding hypertension and cardiovascular disease in patients with end-stage kidney disease. RECENT

findingsFactors such as anemia, valvular and vascular calcification, vasoconstrictors, uremic toxins, hypoglycemia, carbamylated proteins, oxidative stress, and inflammation have all been associated with the progression of cardiovascular disease in end-stage kidney disease but the causality of these mechanisms has not been proven. The high risk of cardiovascular mortality has not improved as in the general population despite many advancements in cardiovascular care over the last two decades. Mechanisms that increase hypertension risk in these patients are centered on the control of extracellular fluid volume; however, over-correction of volume with dialysis can increase risks of intradialytic hypotension and death in these patients. This review presents both recent and classic work that increases our understanding of hypertension and cardiovascular disease in end-stage kidney disease.

Indexed as

Cardiovascular DiseasesHypertensionKidney Failure, ChronicHumansRenal DialysisVasoconstrictor AgentsVasoconstrictor AgentsDialysisEnd-stage kidney diseaseHypertension

Identifiers

PMID35708820
PMCPMC10041674
OpenAlexW4282982674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.