ArticleeLife2022
Self-organization of in vitro neuronal assemblies drives to complex network topology.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
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- Hierarchical Afferent Connectivity Drives Population-Wide Bursting Dynamics in a Computational Model of Human-Derived Excitatory Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Establishing mouse forebrain organoids as models of intrinsic cortical network assembly.Stem cell reports · 2026Article
- Mapping spatial organization of in vitro neuronal networks using high-content imaging.Scientific reports · 2025Article
- Endothelial Cell Organization Drives Distinct Agonist-Specific CaActa physiologica (Oxford, England) · 2025Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
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- Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures.bioRxiv : the preprint server for biology · 2025Article
- Digitoids: a novel computational platform for mimicking oxygen-dependent firing of neuronsFrontiers in neuroinformatics · 2025Article
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Nanomagnetic Guidance Shapes the Structure-Function Relationship of Developing Cortical Networks.Nano letters · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains.PLoS computational biology · 2024Article
- Adaptive rewiring: a general principle for neural network development.Frontiers in network physiology · 2024Review
- Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network.Network neuroscience (Cambridge, Mass.) · 2024Article
- Retinal waves in adaptive rewiring networks orchestrate convergence and divergence in the visual system.Network neuroscience (Cambridge, Mass.) · 2024Article
- Tuning Criticality through Modularity in Biological Neural Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Functional and spatial rewiring principles jointly regulate context-sensitive computation.PLoS computational biology · 2023Article
- Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks.Neuroscience bulletin · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity-dependent self-organization plays an important role in the formation of specific and stereotyped connectivity patterns in neural circuits. By combining neuronal cultures, and tools with approaches from network neuroscience and information theory, we can study how complex network topology emerges from local neuronal interactions. We constructed effective connectivity networks using a transfer entropy analysis of spike trains recorded from rat embryo dissociated hippocampal neuron cultures between 6 and 35 days in vitro to investigate how the topology evolves during maturation. The methodology for constructing the networks considered the synapse delay and addressed the influence of firing rate and population bursts as well as spurious effects on the inference of connections. We found that the number of links in the networks grew over the course of development, shifting from a segregated to a more integrated architecture. As part of this progression, three significant aspects of complex network topology emerged. In agreement with previous in silico and in vitro studies, a small-world architecture was detected, largely due to strong clustering among neurons. Additionally, the networks developed in a modular topology, with most modules comprising nearby neurons. Finally, highly active neurons acquired topological characteristics that made them important nodes to the network and integrators of modules. These findings leverage new insights into how neuronal effective network topology relates to neuronal assembly self-organization mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.