Evidence map›Paper›PMID 35708483›Full record

ArticleeLife2022

Multiple timescales of sensory-evidence accumulation across the dorsal cortex.

Lucas Pinto, David W Tank, Carlos D Brody

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Neural Oscillation as a Selective Modulatory Mechanism on Decision Confidence, Speed, and Accuracy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Sleep Modulates Neural Timescales and Spatiotemporal Integration in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Review
  15. Astrocyte Calcium Signaling.Cold Spring Harbor perspectives in biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Lucas PintoDepartment of Neuroscience, Northwestern University, Chicago, United States.ORCID 0000-0002-0471-9317
David W Tank *Princeton Neuroscience Institute, Princeton University, Princeton, United States.ORCID 0000-0002-9423-4267
Carlos D Brody *Princeton Neuroscience Institute, Princeton University, Princeton, United States.ORCID 0000-0002-4201-561X
Princeton University · US

Funding

Mechanisms of neural circuit dynamics in working memoryU01NS090541 · NINDS · PRINCETON UNIVERSITY · PI BIALEK, WILLIAM, BRODY, CARLOS D · 2014 to 2016
$3.1M
Mechanisms Underlying Large-Scale Coordination of Cortical Activity During Perceptual DecisionsR00MH120047 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PINTO, LUCAS · 2021 to 2023
$741k
Mechanisms underlying large-scale coordination of cortical activity during perceptual decisionsK99MH120047 · NIMH · PRINCETON UNIVERSITY · PI PINTO, LUCAS · 2019 to 2020
$217k
Large- and meso-scale cortical dynamics underlying evidence accumulation and decision-makingF32NS101871 · NINDS · PRINCETON UNIVERSITY · PI PINTO, LUCAS · 2017 to 2018
$117k
NIMH NIH HHS K99 MH120047NIMH NIH HHS R00 MH120047NINDS NIH HHS F32 NS101871NINDS NIH HHS U01 NS090541
6 · The paper itself

Abstract

Cortical areas seem to form a hierarchy of intrinsic timescales, but the relevance of this organization for cognitive behavior remains unknown. In particular, decisions requiring the gradual accrual of sensory evidence over time recruit widespread areas across this hierarchy. Here, we tested the hypothesis that this recruitment is related to the intrinsic integration timescales of these widespread areas. We trained mice to accumulate evidence over seconds while navigating in virtual reality and optogenetically silenced the activity of many cortical areas during different brief trial epochs. We found that the inactivation of all tested areas affected the evidence-accumulation computation. Specifically, we observed distinct changes in the weighting of sensory evidence occurring during and before silencing, such that frontal inactivations led to stronger deficits on long timescales than posterior cortical ones. Inactivation of a subset of frontal areas also led to moderate effects on behavioral processes beyond evidence accumulation. Moreover, large-scale cortical Ca

Indexed as

Task Performance and AnalysisAnimalsMicecortexdecision-makingevidence accumulationintrinsic timescalesmouseneuroscienceoptogeneticsvirtual reality

Identifiers

PMID35708483
PMCPMC9203055
OpenAlexW4283016794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.