ReviewDepression and anxiety2022
Involvement of the brain-heart axis in the link between PTSD and cardiovascular disease.
Review in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Systematic review and meta-analysis of propranolol in the prevention and treatment of post-traumatic stress disorder.Frontiers in pharmacology · 2025Pooled it
- [The role of psychosocial risk factors in the development and course of atrial fibrillation].Herzschrittmachertherapie & Elektrophysiologie · 2026Review
- The brain and heart-axis in neurodegeneration and cardiovascular disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- DNA Methylation as a Mediator of Cardiovascular Disease Risk in Relation to PTSD Severity: Identification of Potential Epigenetic Biomarkers.medRxiv : the preprint server for health sciences · 2026Article
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
- Body-based therapies and transcranial magnetic stimulation for posttraumatic stress disorder: a proposed integrative approach.Frontiers in psychiatry · 2026Review
- Application of stellate ganglion modulation in mental disorders and the future prospects of physical therapies.Fundamental research · 2026Review
- Post-Traumatic Stress Disorder (PTSD) and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Precision psychiatry roadmap: towards a biology-informed framework for mental disorders.Molecular psychiatry · 2025Review
- ECG Signal Analysis for Detection and Diagnosis of Post-Traumatic Stress Disorder: Leveraging Deep Learning and Machine Learning Techniques.Diagnostics (Basel, Switzerland) · 2025Article
- Development and validation of a risk prediction model for post-traumatic stress disorder among Chinese breast cancer survivors.Scientific reports · 2025Article
- No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study.Brain, behavior, and immunity · 2025Article
- Review
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure.European heart journal · 2024Article
- REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals.bioRxiv : the preprint server for biology · 2024Article
- Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The impact of PTSD on associations between sex hormones and cardiovascular disease symptoms.European journal of psychotraumatology · 2024Article
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number of mechanisms have been implicated to underlie this brain-heart axis relationship, such as altered functioning of the autonomic nervous system and increased systemic inflammation. While neural alterations have repeatedly been observed in PTSD, they are rarely considered in the PTSD-CVD link. The brain-heart axis is a pathway connecting frontal and limbic brain regions to the brainstem and periphery via the autonomic nervous system and it may be a promising model for understanding CVD risk in PTSD given its overlap with PTSD neural deficits. We first provide a summary of the primary mechanisms implicated in the association between PTSD and CVD. We then review the brain-heart axis and its relevance to PTSD, as well as findings from PTSD trials demonstrating that a number of PTSD treatments have effects on areas of the brain-heart axis. Finally, we discuss sex considerations in the PTSD-CVD link. A critical next step in this study is to determine if PTSD treatments that affect the brain-heart axis (e.g., brain stimulation that improves autonomic function) also reduce the risk of CVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.