ArticleJournal of clinical laboratory analysis2022
Blood T-helper 17 cells and interleukin-17A correlate with the elevated risk of postpartum depression and anxiety.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The immune phenotype of perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan.Brain, behavior, and immunity · 2024Trial
- Examining the association between prenatal inflammation and postpartum depression in a large, prospective pregnancy cohort in New York City.Brain, behavior, and immunity · 2026Article
- Limited nesting stress in mice as a model to study neuroimmune relationships in postpartum depression.Journal of neuroendocrinology · 2026Article
- Association of inflammatory biomarkers during pregnancy and the postpartum period with the risk of postpartum anxiety symptoms.Brain, behavior, & immunity - health · 2026Article
- Anxiety is associated with systemic pro-inflammatory profile and plasma lipid changes in Mexican young adults.Frontiers in cellular neuroscience · 2026Article
- Blocking IL-17A inhibits methamphetamine-induced hyperlocomotion and conditioned place preference and prevents methamphetamine abstinence-induced depression-like behaviors in mice.Neuropharmacology · 2025Article
- Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025Review
- Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.Expert review of clinical immunology · 2025Review
- Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications.Frontiers in cellular and infection microbiology · 2025Review
- The pathophysiology of estrogen in perinatal depression: conceptual update.Archives of women's mental health · 2024Review
- Recent Progress in Biosensors for Depression Monitoring-Advancing Personalized Treatment.Biosensors · 2024Review
- Regulatory T-cell phenotypes in prenatal psychological distress.Brain, behavior, and immunity · 2024Article
- Impact of the gut microbiota-Th17 cell axis on inflammatory depression.Frontiers in psychiatry · 2024Review
- Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Review
- Biomarkers of Postpartum Depression: A Narrative Review.Journal of clinical medicine · 2023Review
- Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?International journal of molecular sciences · 2022Review
- Blood T-helper 17 cells and interleukin-17A correlate with the elevated risk of postpartum depression and anxiety.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundT-helper (Th) cells regulate inflammation and immunity, which is implicated in psychological disorders. The current study aimed to explore the clinical role of blood Th1, Th2, and Th17 cells and their main secreted cytokines in postpartum depression (PPD) and postpartum anxiety (PPA).
methodsA total of 226 postpartum women were included. At 6 weeks postpartum, Edinburgh Postnatal Depression Scale (EPDS) and State Trait Anxiety Inventory 6 item version (STAI6) scores were assessed; meanwhile, blood Th1, Th2, and Th17 cells were detected by flow cytometry, serum interferon-gamma (IFN-γ), interleukin-4 (IL-4), and IL-17A were detected by enzyme-linked immunosorbent assay.
resultsThe incidence of PPD and PPA were 24.3% and 27.9%, respectively. Th17 cells and IL-17A were positively correlated with EPDS score and STAI6 score (all p < 0.001). Besides, Th17 cells (p < 0.001) and IL-17A (p = 0.002) were increased in PPD cases vs. non-PPD cases, and they were also elevated in PPA cases vs. non-PPA cases (both p < 0.05). However, Th1 cells, Th2 cells, IFN-γ, and IL-4 were not linked with EPDS score or STAI6 score (all p > 0.05); besides, they did not vary in PPD cases vs. non-PPD cases or in PPA cases vs. non-PPA cases (all p > 0.05). Multivariate logistic regression model analysis showed that Th17 cells were independently associated with an elevated risk of PPD (odds ratio [OR] = 1.600, p = 0.001) and PPA (OR = 1.371, p = 0.022).
conclusionBlood Th17 cells and IL-17A are positively linked with the risk of PPD and PPA, indicating which may be involved in the development of PPD and PPA.
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