ArticleJournal of clinical laboratory analysis2022
The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Development and internal validation of an interpretable machine learning prognostic prediction model for postoperative delirium after esophagectomy.Journal of thoracic disease · 2026Article
- Association of preoperative monocyte level with postoperative delirium in patients receiving cardiac surgery under propofol-based anesthesia: a retrospective study.Journal of cardiothoracic surgery · 2026Article
- Clinical Relevance of Preoperative Lymphocyte-to-Monocyte Ratio in Predicting Postoperative Delirium Across Frailty Status in Older Surgical Patients.Clinical interventions in aging · 2026Article
- Perioperative Profiles of Immune Cells in Patients with Postoperative Delirium After Cardiac Surgery with Cardiopulmonary Bypass.Biomedicines · 2025Article
- A clinical prediction model for postoperative delirium following surgical treatment of femoral fractures in older adult patients: development and validation study.BMC anesthesiology · 2025Article
- Nomogram predictive model for the incidence and risk factors of persistent fever after cardiovascular surgery.BMC surgery · 2025Article
- A nomogram model to predict postoperative delirium in esophageal cancer patients undergoing esophagectomy.BMC cancer · 2025Article
- Comparative analysis of inflammatory markers as predictive markers for postoperative delirium in cardiac surgery patients: an observational study.Frontiers in medicine · 2025Article
- Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study.BMC geriatrics · 2024Article
- A machine learning-based prediction model for postoperative delirium in cardiac valve surgery using electronic health records.BMC cardiovascular disorders · 2024Article
- Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Thoracic delirium index for predicting postoperative delirium in elderly patients following thoracic surgery: A retrospective case-control study.Brain and behavior · 2024Observational
- Prognostic Value of the Baseline and Early Changes in Monocyte-to-Lymphocyte Ratio for Short-Term Mortality among Critically Ill Patients with Acute Kidney Injury.Journal of clinical medicine · 2023Article
- The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery.Journal of clinical laboratory analysis · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the relationship between monocyte-to-lymphocyte ratio (MLR) and postoperative delirium (POD).
methodsThis cohort study was conducted in the Medical Information Mart for Intensive Care-III (MIMIC-III) version 1.4 database. MLR was measured according to the complete blood count. ICD-9 was used to measure postoperative delirium. Multivariable logistic regression was utilized to examine the relationship between MLR and POD.
resultsThree thousand eight hundred sixty-eight patients who had received cardiac surgery were retrospectively enrolled, including 2171 males and 1697 females, with a mean age of 63.9 ± 16.2 years. The univariate analysis suggested that high MLR (as a continuous variable) as associated with a 21% higher risk of POD (O R: 1.12, 95% CI, 1.02, 1.43, p = 0.0259), After adjustments for other confounding factors, gender, age, race, temperature, SBP, DBP, MAP, respiratory rate, SOFA, peripheral vascular disease, AG, psychoses, drug, and alcohol addiction, the results showed that high MLR (as a continuous variable) independently served as a risk factor for POD (OR: 1.21; 95% CI: 1.01-1.44; p = 0.0378). MLR was assessed as quintile and tertiles, high MLR was an independent risk factor for POD. In the subgroup analysis, there were no differences in MLR for patients with POD in pre-specified subgroups.
conclusionsMonocyte-to-lymphocyte ratio was a risk factor for POD. More research is necessary to thoroughly examine the function of MLR in POD.
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