ArticleCNS neuroscience & therapeutics2022
Elevated pulsatility index is associated with poor functional outcome in stroke patients treated with thrombectomy: A retrospective cohort study.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06361017 (Research of the Prediction of Hemorrhage Transformation and Clinical Outcome by Cerebral Autoregulation After Endovascular Thrombectomy in Acute Ischemic Stroke Patients Caused by Middle Cerebral Artery or Internal Carotid Artery Occlusion.), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Research of the Prediction of Hemorrhage Transformation and Clinical Outcome by Cerebral Autoregulation After Endovascular Thrombectomy in Acute Ischemic Stroke Patients Caused by Middle Cerebral Artery or Internal Carotid Artery Occlusion.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Association between the no-reflow phenomenon and clinical outcomes after endovascular treatment for acute ischemic stroke: A systematic review and meta-analysis.European stroke journal · 2026Pooled it
- Transcranial doppler (TCD) in predicting outcomes following successful mechanical thrombectomy of large vessel occlusions in anterior circulation: a systematic review and meta-analysis.Journal of neurointerventional surgery · 2025Pooled it
- Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Combined ipsilateral peak systolic velocity and ASPECTS are associated with early neurological deterioration after endovascular thrombectomy: a prospective cohort study.BMC neurology · 2026Article
- Pulsatility index: Insights into post-stroke haemodynamics.Neuroscience insights · 2026Review
- Prognostic Value of Cerebral Hemodynamics Assessment on 24-h Transcranial Color-Coded Doppler Following a Successful Thrombectomy.European journal of neurology · 2025Observational
- Mitigating Early Phosphatidylserine Exposure in a Tmem30a-Dependent Way Ameliorates Neuronal Damages After Ischemic Stroke.MedComm · 2025Article
- No impact of intravenous thrombolysis on post thrombectomy transcranial Doppler pulsatility index.Frontiers in neurology · 2025Article
- Analyzing post-endovascular treatment stroke prognosis with transcranial Doppler and quantitative electroencephalography.Annals of clinical and translational neurology · 2024Article
- No-reflow after stroke reperfusion therapy: An emerging phenomenon to be explored.CNS neuroscience & therapeutics · 2024Review
- Transcranial Doppler After Successful Endovascular Revascularization and Hospitalization Outcomes.Stroke (Hoboken, N.J.) · 2023Article
- A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Low serum magnesium is associated with poor functional outcome in acute ischemic stroke or transient ischemic attack patients.CNS neuroscience & therapeutics · 2023Article
- Elevated pulsatility index is associated with poor functional outcome in stroke patients treated with thrombectomy: A retrospective cohort study.CNS neuroscience & therapeutics · 2022Article
- No-reflow phenomenon following stroke recanalization therapy: Clinical assessment advances: A narrative review.Brain circulationReview
- Association of Early M2 Pulsatility Index Ratio With Outcomes After Successful Endovascular Thrombectomy.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate pulsatility index (PI) in patients with acute ischemic stroke (AIS) who underwent endovascular thrombectomy (EVT).
methodsPatients were retrospectively recruited if their stroke were secondary to middle cerebral artery (MCA) occlusion and achieved full recanalization after EVT. Transcranial Doppler was performed within 24-hour post-EVT. The primary outcome was correlation between the MCA-PI on the affected side and 3-month functional outcome, with modified Rankin scale (mRS) ≥5 indicated extremely poor functional outcomes.
resultsTotally, 170 patients were included. High MCA-PI was positively related to the 3-month mRS score (r = 0.288, p < 0.001). The highest quartile of the MCA-PI was associated with a high incidence of extremely poor functional outcomes (adjusted OR, 13.33; 95% CI, 2.65-67.17; adjusted p = 0.002) after adjusting for confounding factors. The predictive capacity of the MCA-PI for extremely poor functional outcomes was good (area under the curve, 0.755; 95% CI, 0.655-0.854; p < 0.001), and its cutoff value for predicting extremely poor outcomes was 1.04, with a sensitivity of 65.6% and specificity of 78.3%.
conclusionThe MCA-PI on the affected side is a prognostic biomarker in patients who have undergone stroke thrombectomy. An elevated MCA-PI may be prognostically valuable for predicting extremely poor functional outcomes.
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