ArticleObesity (Silver Spring, Md.)2022
Lymphatic function and anatomy in early stages of lipedema.
Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Effect of pneumatic compression device and stocking use on symptoms and quality of life in women with lipedema: A proof-in-principle randomized trial.Phlebology · 2023Trial
- Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema.Life (Basel, Switzerland) · 2026Article
- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- Lipedema and obesity: A narrative review and treatment protocol.JPRAS open · 2026Review
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- The role of physical therapy in the treatment of lipedema: an integrative review of therapeutic strategies and the current clinical landscape.Jornal vascular brasileiro · 2026Review
- Vascular changes and their implications in lipedema.Frontiers in cell and developmental biology · 2026Review
- New Characterization of Lipedema Stages: Focus on Pain, Water, Fat and Skeletal Muscle.Life (Basel, Switzerland) · 2025Article
- An Advanced Pneumatic Compression Therapy System Improves Leg Volume and Fluid, Adipose Tissue Thickness, Symptoms, and Quality of Life and Reduces Risk of Lymphedema in Women with Lipedema.Life (Basel, Switzerland) · 2025Article
- Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice.Developmental cell · 2025Article
- Metabolic Alterations in Women with Lipedema Compared to Women with Lifestyle-Induced Overweight/Obesity.Biomedicines · 2025Article
- Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema.Obesity (Silver Spring, Md.) · 2025Article
- Lipedema and adipose tissue: current understanding, controversies, and future directions.Frontiers in cell and developmental biology · 2025Review
- Using four-point subcutaneous injection of lymphatic contrast-enhanced ultrasound to diagnose lymphedema of lower extremity.Quantitative imaging in medicine and surgery · 2024Article
- A Review of Image Sensors Used in Near-Infrared and Shortwave Infrared Fluorescence Imaging.Sensors (Basel, Switzerland) · 2024Review
- Proposed Framework for Research Case Definitions of Lipedema.Lymphatic research and biology · 2024Review
- National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States.Vascular medicine (London, England) · 2024Article
- Lipedema: exploring pathophysiology and treatment strategies - state of the art.Jornal vascular brasileiro · 2024Review
- Lipedema Reduction Surgery Improves Pain, Mobility, Physical Function, and Quality of Life: Case Series Report.Plastic and reconstructive surgery. Global open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLipedema is an inflammatory subcutaneous adipose tissue disease that develops in women and may progress to lipolymphedema, a condition similar to lymphedema, in which lymphatic dysfunction results in irresolvable edema. Because it has been shown that dilated lymphatic vessels, impaired pumping, and dermal backflow are associated with presymptomatic, cancer-acquired lymphedema, this study sought to understand whether these abnormal lymphatic characteristics also characterize early stages of lipedema prior to lipolymphedema development.
methodsIn a pilot study of 20 individuals with Stage I or II lipedema who had not progressed to lipolymphedema, lymphatic vessel anatomy and function in upper and lower extremities were assessed by near-infrared fluorescence lymphatic imaging and compared with that of a control population of similar age and BMI.
resultsThese studies showed that, although lower extremity lymphatic vessels were dilated and showed intravascular pooling, the propulsion rates significantly exceeded those of control individuals. Upper extremity lymphatics of individuals with lipedema were unremarkable. In contrast to individuals with lymphedema, individuals with Stage I and II lipedema did not exhibit dermal backflow.
conclusionsThese results suggest that, despite the confusion in the diagnoses between lymphedema and lipedema, their etiologies differ, with lipedema associated with lymphatic vessel dilation but not lymphatic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.