ArticleIBRO neuroscience reports2022
Endogenous dopamine transmission is crucial for motor skill recovery after stroke.
Article in IBRO neuroscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial.Nature medicine · 2026Trial
- The Use of Extrinsic Performance Feedback and Reward to Enhance Upper Limb Motor Behavior and Recovery Post-Stroke: A Scoping Review.Neurorehabilitation and neural repair · 2025Article
- Neuroprotective effect of L-DOPA-induced interleukin-13 on striatonigral degeneration in cerebral ischemia.Cell death & disease · 2024Article
- Review
- The role of ventral tegmental area in chronic stroke rehabilitation: an exploratory study.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke frequently causes motor impairments. Despite exercise can improve motor outcomes, many stroke survivors remain life-long disabled. Understanding the mechanisms associated with motor recovery after a stroke is necessary to develop treatments. Here, we show that endogenous DA transmission is required for optimal motor skill recovery following photothrombotic stroke in rats. Blockade of dopamine D1 and D2 receptors impaired the recovery of a forelimb reaching task and decreased the rats' motivation to complete full training sessions. Our data indicate that dopamine transmission is important to drive motor rehabilitation after stroke through motivational aspects and ultimately suggest that augmented motivation and reward feedback could be an interesting strategy to increase the effectiveness or rehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.