Evidence map›Paper›PMID 35707284›Full record

SynthesisSkin appendage disorders2022

Hematohidrosis, Hemolacria, and "Trichorrhage": A Systematic Review.

Diego Carrion-Alvarez, Alejandro I Trejo-Castro, Mauricio Salas-Garza, Oscar Raul Fajardo-Ramirez, Julio Cesar Salas-Alanis

Abstract readSystematic Review
In one paragraph

Synthesis in Skin appendage disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Hematohidrosis in a Child.Indian journal of pediatrics · 2026
    Article
  4. Hematohidrosis: A Rare Case of Blood Sweating.Cardiovascular & hematological disorders drug targets · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diego Carrion-AlvarezDystrophic Epidermolysis Bullosa Research Association, Guadalupe, Mexico.
Alejandro I Trejo-CastroSchool of Engineering and Sciences, Tecnológico de Monterrey, Monterrey, Mexico.
Mauricio Salas-GarzaSchool of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, Mexico.
Oscar Raul Fajardo-RamirezSchool of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, Mexico.
Julio Cesar Salas-AlanisInstituto Dermatológico de Jalisco, Guadalajara, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hematohidrosis and hemolacria are 2 conditions surrounded in religiousness, mysticism, and supernatural superstitions. While the mechanism is still unclear, these cases have amazed physicians for centuries. Methods: We performed a systematic review in PubMed from 2000 to mid-2021 accounting for 75 studies from which we included 60 cases in 53 articles which were described. Results: The median age of apparition was 24 years with the youngest case being 12 and the oldest 81. Some of the diseases were secondary to other causes such as hemangiomas and other neoplasias or epistaxis episodes. Most of the cases have been reported in India and the USA; most of them correspond to hemolacria alone (51.6%). Discussion: We have stated the basics of the substances involved in the coagulation process that have been described as genetically altered in some patients such as mucins, metalloproteinases, and fibrinogen, as well as propose a mechanism that can explain the signs of this particular entity and approach to its treatment as well as provide the first trichoscopy image of a patient with hemolacria.

Indexed as

HematohidrosisHemolacriaTrichorrhage

Identifiers

PMID35707284
PMCPMC9149430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.