ArticleOxidative medicine and cellular longevity2022
Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver.
Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- A narrative review of dietary patterns in cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2026Review
- Ketogenic diet strategy in patients with sepsis: a multicentre prospective randomised interventional trial protocol.BMJ open · 2025Article
- Ketone Body Induction: Insights into Metabolic Disease Management.Biomedicines · 2025Review
- Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond.Cardiovascular research · 2024Review
- Impact of ketogenic diet on cardiovascular disease.Nutrition reviews · 2024Review
- The ketogenic diet has the potential to decrease all-cause mortality without a concomitant increase in cardiovascular-related mortality.Scientific reports · 2024Article
- Review
- The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure.Cardiovascular research · 2024Article
- Molecular Aspects of Cardiometabolic Diseases: From Etiopathogenesis to Potential Therapeutic Targets.International journal of molecular sciences · 2024Article
- Ketogenic diet induces p53-dependent cellular senescence in multiple organs.Science advances · 2024Article
- Myocardial Metabolism in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2024Review
- Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery.Acta pharmacologica Sinica · 2024Review
- Ketogenic diet and behavior: insights from experimental studies.Frontiers in nutrition · 2024Review
- The Ketogenic Diet and Cardiovascular Diseases.Nutrients · 2023Review
- Ketones and the cardiovascular system.Nature cardiovascular research · 2023Review
- Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue.International journal of molecular sciences · 2023Review
- Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention.Frontiers in nutrition · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As heart failure develops, the heart utilizes ketone bodies at increased rates, indicating an adaptive stress response. Thus, increasing ketone body availability exerts protective effects against heart failure. However, although it is the widely used approach for increasing ketone body availability, the ketogenic diet shows limited cardioprotective effects against heart failure. This study was aimed at examining the effects of the ketogenic diet on heart failure and the underlying mechanisms. Pressure overload-induced heart failure was established by transverse aortic constriction (TAC) in mice. Continuous ketogenic diet feeding for 8 weeks failed to protect the heart against heart failure. It showed no significant effects on cardiac systolic function and fibrosis but aggravated cardiac diastolic function in TAC mice. Specifically, it induced systemic lipid metabolic disorder and hepatic dysfunction in TAC mice. It decreased the content of 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), a key enzyme in ketogenesis, and impaired the capacity of hepatic ketogenesis in TAC mice. It preserved the capacity of hepatic ketogenesis and exerted cardioprotective effects against heart failure, increasing cardiac function and decreasing cardiac fibrosis, in liver-specific HMGCL-overexpressed TAC mice. Importantly, we found that alternate-day ketogenic diet feeding did not impair the capacity of hepatic ketogenesis and exerted potent cardioprotective effects against heart failure. These results suggested that alternate-day but not continuous ketogenic diet protects against heart failure through preservation of ketogenesis in the liver.
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