Evidence map›Paper›PMID 35707205›Full record

ArticlePNAS nexus2022

Cross-species metabolomic analysis of tau- and DDT-related toxicity.

Vrinda Kalia, Megan M Niedzwiecki, Joshua M Bradner, Fion K Lau, Faith L Anderson, Meghan L Bucher, Katherine E Manz, Alexa Puri Schlotter, Zoe Coates Fuentes, Kurt D Pennell and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Vrinda KaliaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.ORCID https://orcid.org/0000-0003-2244-6663
Megan M NiedzwieckiDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029 USA.
Joshua M BradnerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.
Fion K LauDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.
Faith L AndersonDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.
Meghan L BucherDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.
Katherine E ManzSchool of Engineering, Brown University, Providence, RI, 02912 USA.
Alexa Puri SchlotterDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.
Zoe Coates FuentesDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029 USA.
Kurt D PennellSchool of Engineering, Brown University, Providence, RI, 02912 USA.
Martin PicardDepartment of Neurology, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, 10032 USA.ORCID https://orcid.org/0000-0003-2835-0478
Douglas I WalkerDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029 USA.
William T HuDepartment of Neurology, Rutgers Biomedical and Health Sciences, New Brunswick, NJ, 08901 USA.
Dean P JonesDivision of Pulmonary, Allergy and Critical Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, 30322 USA.
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 10032 USA.ORCID https://orcid.org/0000-0001-8984-1284
Columbia University · USIcahn School of Medicine at Mount Sinai · USBrown University · USColumbia University Irving Medical Center · USEmory University · USRutgers, The State University of New Jersey · US

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
A Practical Tool for Managing the Complexity of Biologics Process ManufacturingR44TR000187 · NCATS · ADVANCED PROCESS COMBINATORICS, INC. · PI PEKNY, JOSEPH F · 2014 to 2015
$1.2M
A Practical Tool for Managing the Complexity of Biologics Process ManufacturingR43TR000187 · NCATS · ADVANCED PROCESS COMBINATORICS, INC. · PI PEKNY, JOSEPH F · 2012 to 2012
$150k
NCATS NIH HHS R43 TR000187NCATS NIH HHS R44 TR000187NIEHS NIH HHS P30 ES023515NIEHS NIH HHS U2C ES030859
6 · The paper itself

Abstract

Exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) has been associated with increased risk of Alzheimer's disease (AD), a disease also associated with hyperphosphorylated tau (p-tau) protein aggregation. We investigated whether exposure to DDT can exacerbate tau protein toxicity in

Indexed as

Alzheimer's diseaseC. elegansDDTmetabolomicstau protein

Identifiers

PMID35707205
PMCPMC9186048
OpenAlexW4229065868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.