ArticleJournal of inflammation research2022
CREST Syndrome in Systemic Sclerosis Patients - Is Dystrophic Calcinosis a Key Element to a Positive Diagnosis?
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Coexistence of Localized and Systemic Juvenile Scleroderma: A Case Report and Review of Literature.Clinical case reports · 2025Article
- Severe Spinal Stenosis Secondary to a CREST Syndrome Related Calcific Deposit: A Case Report.Spine surgery and related research · 2025Article
- Article
- Epigastric discomfort in a young woman: unveiling a case of CREST syndrome.Annals of medicine and surgery (2012) · 2024Article
- Serum Caspase-3 Levels as a Predictive Molecular Biomarker for Acute Ischemic Stroke.International journal of molecular sciences · 2024Article
- Immunogenetics of Systemic Sclerosis.Genes · 2024Review
- The Association of Telangiectasias with Other Peripheral Vascular Lesions of Systemic Sclerosis.Clinical, cosmetic and investigational dermatology · 2024Article
- Efficiency of continuous positive airway pressure and high-flow nasal oxygen therapy in critically ill patients with COVID-19.The Journal of international medical research · 2024Article
- Recurrent uveitis in a patient with CREST syndrome: a case report.Annals of medicine and surgery (2012) · 2023Article
- Surgical Management of Perianal Giant Condyloma Acuminatum of Buschke and Löwenstein: Case Presentation.Life (Basel, Switzerland) · 2023Article
- The Gut Microbial Metabolite Trimethylamine N-Oxide is Linked to Specific Complications of Systemic Sclerosis.Journal of inflammation research · 2023Article
- Pathogenesis of Musculotendinous and Fascial Injuries After Physical Exercise - Short Review.International journal of general medicine · 2023Review
- Immunologic and nonimmunologic sclerodermal skin conditions - review.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: CREST syndrome is a clinical entity associated with systemic sclerosis, which meets at least three of the five clinical features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. Three of these clinical features (Raynaud's phenomenon, sclerodactyly and esophageal dysmotility) are often present in classical subsets of SSc: limited and diffuse, and their presence in association does not define CREST syndrome. Calcinosis seems to be less common in SSc and its association with other clinical features is characteristic of CREST syndrome. Therefore, it can be appreciated that calcinosis is the key element of CREST syndrome. Methods: This study included a number of 37 candidates with SSc, diagnosed with the help of the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2013 criteria. Results and Discussions: These three elements (calcinosis, Raynaud's phenomenon, esophageal dysmotility) were recorded both in the limited subset of SSc, but especially in the subset of diffuse SSc, contrary to the data in the literature. Conclusion: We appreciate that CREST syndrome is a clinical entity that can overlap with both subsets of SSc. Given the divergent views of the authors on the classification of CREST syndrome, future studies may contribute to a reassessment of SSc classification.
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