Evidence map›Paper›PMID 35706352›Full record

ArticleInternational journal of methods in psychiatric research2022

New-onset and persistent neurological and psychiatric sequelae of COVID-19 compared to influenza: A retrospective cohort study in a large New York City healthcare network.

Andrei L Iosifescu, Wouter S Hoogenboom, Alexandra J Buczek, Roman Fleysher, Tim Q Duong

Open access · goldAbstract read
In one paragraph

Article in International journal of methods in psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  20. Long COVID: Long-Term Impact of SARS-CoV2.Diagnostics (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrei L IosifescuDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Wouter S HoogenboomDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-4702-2114
Alexandra J BuczekDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Roman FleysherDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Tim Q DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Albert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNeurological and neuropsychiatric manifestations of post-acute SARS-CoV-2 infection (neuro-PASC) are common among COVID-19 survivors, but it is unknown how neuro-PASC differs from influenza-related neuro-sequelae. This study investigated the clinical characteristics of COVID-19 patients with and without new-onset neuro-PASC, and of flu patients with similar symptoms.

methodsWe retrospectively screened 18,811 COVID-19 patients and 5772 flu patients between January 2020 and June 2021 for the presence of new-onset neuro-sequelae that persisted at least 2 weeks past the date of COVID-19 or flu diagnosis.

resultsWe observed 388 COVID-19 patients with neuro-PASC versus 149 flu patients with neuro-sequelae. Common neuro-PASC symptoms were anxiety (30%), depression (27%), dizziness (22%), altered mental status (17%), chronic headaches (17%), and nausea (11%). The average time to neuro-PASC onset was 138 days, with hospitalized patients reporting earlier onset than non-hospitalized patients. Neuro-PASC was associated with female sex and older age (p < 0.05), but not race, ethnicity, most comorbidities, or COVID-19 disease severity (p > 0.05). Compared to flu patients, COVID-19 patients were older, exhibited higher incidence of altered mental status, developed symptoms more quickly, and were prescribed psychiatric drugs more often (p < 0.05).

conclusionsThis study provides additional insights into neuro-PASC risk factors and differentiates between post-COVID-19 and post-flu neuro-sequelae.

Indexed as

COVID-19Influenza, HumanDelivery of Health CareFemaleHumansNew York CityRetrospective StudiesSARS-CoV-2COVID-19influenzaneuropsychiatrynew-onset symptoms

Identifiers

PMID35706352
PMCPMC9349863
OpenAlexW4282968890

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.