Evidence map›Paper›PMID 35705965›Full record

ArticleMolecular autism2022

Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort.

Novika Purnama Sari, Pauline W Jansen, Laura M E Blanken, Amber N V Ruigrok, Peter Prinzie, Henning Tiemeier, Simon Baron-Cohen, Marinus H van IJzendoorn, Tonya White

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Novika Purnama SariDepartment Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands. purnamasari@essb.eur.nl.ORCID 0000-0001-6555-0052
Pauline W JansenDepartment Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Laura M E BlankenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Amber N V RuigrokAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Peter PrinzieDepartment Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Simon Baron-CohenAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Marinus H van IJzendoornDepartment Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Tonya WhiteDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Erasmus University Rotterdam · NLErasmus MC · NLUniversity of Cambridge · GBHarvard University · USUniversity of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring.

methodsIn a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M

resultsThe relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers.

conclusionsThe relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms.

Indexed as

Autistic DisorderMentalizationChildFemaleHumansMaleMaternal AgeMothersNetherlandsPregnancyAutistic-like traitsChildrenMaternal ageMentalizing

Identifiers

PMID35705965
PMCPMC9199218
OpenAlexW4282916600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.