Evidence map›Paper›PMID 35705944›Full record

Trial reportBMC pediatrics2022

Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.

Mary Beth Sutter, Hannah Watson, Nicole Yonke, Sherry Weitzen, Lawrence Leeman

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02851303 (Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02851303 phase4completednot on this map

Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome

TypeinterventionalSponsorUniversity of New MexicoRan2016 to 2018Enrolled61ConditionsNeonatal Abstinence SyndromeArmsMorphine, Methadone
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Opioid equipotency conversions for hospitalized infants: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Pooled it
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Mary Beth SutterDepartment of Family Medicine, Alpert Medical School of Brown University, Providence, RI, USA. marybeth_sutter@brown.edu.
Hannah WatsonSanta Rosa Community Health, Santa Rosa, CA, USA.
Nicole YonkeFamily Medicine of Southwest Washington, Vancouver, WA, USA.
Sherry WeitzenBaystate Health, Springfield, MA, USA.
Lawrence LeemanDepartment of Family and Community Medicine, Department of Obstetrics, University of New Mexico, Albuquerque, NM, USA.
Baystate Health · USBrown University · USSouthwest Washington Medical Center · USUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a significant public health issue and while millions of neonates are affected each year, an optimal pharmacologic weaning protocol has yet to be demonstrated. In this study, we compare hospital length of stay (LOS) and length of treatment (LOT) for treatment of neonatal opioid withdrawal (NOWS) with morphine versus methadone.

methodsThis was a single-site, open-label, randomized controlled pilot study conducted from October 2016-September 2018. Infants were eligible if their primary in-utero drug exposure was heroin, oral opioids, or methadone and they were born at greater than or equal to 34 weeks gestation. Infants were excluded for serious medical comorbidities and primary in-utero exposure to buprenorphine.

resultsSixty-one infants were enrolled; 30 were randomized to methadone treatment, and 31 to morphine treatment. Overall 46% of infants required treatment for NOWS. LOS and LOT for infants treated with morphine was 17.9 days and 14.7 days respectively, compared to 16.1 days and 12.8 days for babies treated with methadone (p = 0.5, p = 0.54). Infants treated with morphine received lower total morphine equivalents than those treated with methadone (9.7 vs. 33, p < 0.01). Three treated infants in the methadone group required transfer to the Neonatal Intensive Care Unit, versus no infants in the morphine group.

conclusionsInfants treated with morphine versus methadone had no significant differences in LOS or LOT in this pilot study. Infants treated with methadone received up to 3 times the opioid based on morphine equivalents as infants treated with morphine and had more transfers to the NICU for over sedation. CLINICAL

trial registrationMorphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome NCT02851303 , initiated 01/08/2016.

Indexed as

Neonatal Abstinence SyndromeAnalgesics, OpioidHumansInfant, NewbornLength of StayMethadoneMorphinePilot ProjectsAnalgesics, OpioidMethadoneMorphineMethadoneNeonatal opioid withdrawal syndromePerinatal substance use disorders

Identifiers

PMID35705944
PMCPMC9202148
OpenAlexW4282928692

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.