Evidence map›Paper›PMID 35705943›Full record

ArticleBMC complementary medicine and therapies2022

In vitro anti-HIV and cytotoxic effects of pure compounds isolated from Croton macrostachyus Hochst. Ex Delile.

Ermias Mergia Terefe, Faith A Okalebo, Solomon Derese, Moses K Langat, Eduard Mas-Claret, Nada H Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Arabinda Ghosh, Eman A El-Masry and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Journal of experimental pharmacology · 2024
    Article
  2. Article
  3. Article
  4. Anti-HIV Ermiasolides fromMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 6 countries.

Ermias Mergia TerefeDepartment of Pharmacology and Pharmacognosy, School of Pharmacy and Health Sciences, United States International University-Africa, P.O. BOX 14634 - 00800, Nairobi, Kenya. eterefe@usiu.ac.ke.
Faith A OkaleboDepartment of Pharmacology and Pharmacognosy, College of Health Sciences, University of Nairobi, Nairobi, Kenya.
Solomon DereseDepartment of Chemistry, University of Nairobi, Nairobi, Kenya.
Moses K LangatRoyal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK.
Eduard Mas-ClaretRoyal Botanic Gardens, Kew, Kew Green, Richmond, Surrey, TW9 3AE, UK.
Nada H AljarbaDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P. O. Box 84428, Riyadh, 11671, Saudi Arabia.
Saad AlkahtaniDepartment of Zoology, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt.
Arabinda GhoshMicrobiology Division, Department of Botany, Gauhati University, Guwahati, Assam, 781014, India.
Eman A El-MasryMicrobiology and Immunology unit, Department of Pathology, College of Medicine, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
Joseph MuriukiCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Royal Botanic Gardens, Kew · GBUniversity of Nairobi · KEDamanhour University · EGGauhati University · INKenya Medical Research Institute · KEKing Saud University · SAMenoufia University · EGPrincess Nourah bint Abdulrahman University · SAUnited States International University Africa · KE

Funding

King Saud University RSP-2021/26Princess Nourah Bint Abdulrahman University PNURSP2022R62United States International University-Africa 10-2854
6 · The paper itself

Abstract

Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for cough, back pain, bleeding, skin diseases, warts, pneumonia, and wounds. This study aimed to evaluate the anti-HIV activities and cytotoxic effects of extracts and chemical constituents isolated from C. macrostachyus. In our previous study we demonstrated that the hexane, CH

Indexed as

Anti-HIV AgentsCrotonPlant ExtractsHexanesHumansMedicine, African TraditionalPlant LeavesAnti-HIV AgentsHexanesPlant ExtractsAnti-HIVBetulin and cytotoxicity effectsCroton macrostachyusHIV-1LupenoneLupeol acetate

Identifiers

PMID35705943
PMCPMC9202147
OpenAlexW4282935308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.