SynthesisBMC psychiatry2022
The causal relationship between sleep traits and the risk of schizophrenia: a two-sample bidirectional Mendelian randomization study.
Synthesis in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Unveiling the key roles in esophageal cancer drug resistance from a genetic perspective: the interplay between cytokines and immune cell phenotypes.Discover oncology · 2025Article
- Physical Activity, Sleep, and Risk of Late-Onset Severe Mental Illness: A Prospective Cohort Study From UK Biobank.Schizophrenia bulletin · 2025Article
- Sleep duration and its associated factors in schizophrenia patients: a large-scale cross-sectional survey.BMC psychiatry · 2025Article
- Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.Current sleep medicine reports · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
- Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Sleep inertia drives the association of evening chronotype with psychiatric disorders: epidemiological and genetic evidence.medRxiv : the preprint server for health sciences · 2024Article
- Causal relationships between dietary antioxidant vitamin intake and atopic dermatitis: A two-sample Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Establishing causal relationships between insomnia and gestational diabetes mellitus using Mendelian randomization.Heliyon · 2024Article
- The relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model.BMC public health · 2024Article
- Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia.BMC psychiatry · 2024Article
- Causal associations between dietary factors and colorectal cancer risk: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- New insights into the increased risk of migraines from COVID-19 infection and vaccination: a Mendelian randomization study.Frontiers in neurology · 2024Article
- The causal relationship between sleep and risk of psychiatric disorders: A two-sample mendelian randomization study.Frontiers in genetics · 2024Article
- Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study.Behavioral and brain functions : BBF · 2023Article
- Article
- Susceptibility and severity of COVID-19 and risk of psychiatric disorders in European populations: a Mendelian randomization study.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObservational studies suggest that sleep disturbances are commonly associated with schizophrenia. However, it is uncertain whether this relationship is causal. To investigate the bidirectional causal relation between sleep traits and schizophrenia, we performed a two-sample bidirectional Mendelian randomization (MR) study with the fixed effects inverse-variance weighted (IVW) method.
methodsAs genetic variants for sleep traits, we selected variants from each meta-analysis of genome-wide association studies (GWASs) conducted using data from the UK Biobank (UKB).
resultsWe found that morning diurnal preference was associated with a lower risk of schizophrenia, while long sleep duration and daytime napping were associated with a higher risk of schizophrenia. Multivariable MR analysis also showed that sleep duration was associated with a higher risk of schizophrenia after adjusting for other sleep traits. Furthermore, genetically predicted schizophrenia was negatively associated with morning diurnal preference and short sleep duration and was positively associated with daytime napping and long sleep duration.
conclusionsTherefore, sleep traits were identified as a potential treatment target for patients with schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.