Evidence map›Paper›PMID 35705893›Full record

SynthesisBMC cancer2022

The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis.

Jinfeng Shi, Ling Wang, Nan Yao, Le Sun, Wenyu Hu, Xiaotong Li, Yixue Yang, Yusheng Wang, Wei Zhu, Bo Li

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinfeng ShiDepartment of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Xinmin Street No. 71, JiLin, 130021, Changchun, P.R. China.
Ling WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China.
Nan YaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China.
Le SunDepartment of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Xinmin Street No. 71, JiLin, 130021, Changchun, P.R. China.
Wenyu HuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China.
Xiaotong LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China.
Yixue YangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China.
Yusheng WangDepartment of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Xinmin Street No. 71, JiLin, 130021, Changchun, P.R. China.
Wei ZhuDepartment of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Xinmin Street No. 71, JiLin, 130021, Changchun, P.R. China. zhuwei@jlu.edu.cn.
Bo LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street 1163, 130021, Changchun, P. R. China. li_bo@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether the presence of human papillomavirus (HPV) DNA and p16 might be associated with better prognosis in patients with hypopharyngeal carcinoma (HPC), especially on overall survival (OS) and disease-free survival (DFS).

methodPubMed, the Cochrane Library, the Web of Science and EMBASE were searched from inception to April 2021 to search for HPV DNA- and p16-related prognostic articles on HPC. Meta-analysis was performed on the selected articles according to the inclusion and exclusion criteria. Publication bias was assessed for the included studies with Egger's test. All studies were analyzed by using Stata 16.0 statistical software.

resultsA total of 18 studies were included, including 12 HPV DNA studies and 11 p16 studies. Meta-analysis showed that HPV DNA positivity was a strong prognostic factor for improved OS in patients with HPC, with a pooled hazard ratio (HR) of 0.61 (95% CI, 0.54-0.69), but there was no statistically significant difference in DFS (HR, 0.60; 95% CI, 0.31-1.16). Patients with p16-positive tumors had better OS (HR, 0.66; 95% CI, 0.49-0.89) and DFS (HR, 0.59; 95% CI, 0.44-0.78) than patients with p16-negative tumors.

conclusionsThis study suggests that the presence of HPV DNA leads to better OS in patients with HPC, and the presence of p16 also corresponds to better OS and DFS. Our results provide up-to-date evidence to clinicians and researchers. Larger studies adjusting for prognostic factors are needed in subsequent studies.

Indexed as

Carcinoma, Squamous CellHypopharyngeal NeoplasmsPapillomavirus InfectionsCyclin-Dependent Kinase Inhibitor p16DNAHumansPrognosisRetrospective StudiesCyclin-Dependent Kinase Inhibitor p16DNAHuman papilloma virus (HPV)Hypopharyngeal Carcinoma (HPC)Meta-analysisp16Prognostic

Identifiers

PMID35705893
PMCPMC9202146

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.