SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2022
A Comprehensive Review of Hepatic Hemangioma Management.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Comparative effectiveness and safety of robotic versus laparoscopic liver resection for benign liver diseases: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Transarterial embolization with bleomycin-lipiodol for symptomatic multifocal hepatic hemangiomas: Concurrent nontarget lesion devascularization via permitted reflux.Radiology case reports · 2026Article
- Synchronous regression of nontarget hepatic hemangiomas following direct sclerotherapy of a symptomatic giant hemangioma: A report of two cases.Radiology case reports · 2026Article
- Management and Clinical Outcomes of Liver Hemangiomas: A Retrospective Comparative Study of Transcatheter Arterial Embolization and Surgery.Medicina (Kaunas, Lithuania) · 2026Article
- Association of endogenous hypercortisolism with hepatic hemangiomas in cushing's disease: a retrospective cohort study.BMC endocrine disorders · 2026Observational
- "No Touch to Touch": Percutaneous Sclerotherapy of a Giant Hepatic Cavernous Hemangioma.Cureus · 2026Article
- Advancements in hepatic haemangioma surgery: An update-review of protocols, techniques, and postoperative outcomes.World journal of gastrointestinal surgery · 2026Review
- Safety and feasibility of laparoscopic resection for giant hepatic hemangiomas: a retrospective cohort study.BMC surgery · 2026Article
- Successful long-term results (> 5 years) of superselective transarterial chemoembolization in symptomatic/enlarging liver hemangiomas: a paradigm shift at a hepatopancreatobiliary surgery unit.Frontiers in medicine · 2026Article
- Indocyanine green fluorescence navigation versus conventional laparoscopic hepatectomy for hepatic hemangioma: a propensity score matched study.Surgical endoscopy · 2026Article
- Extended Right Hepatectomy for Giant Hepatic Hemangioma: A Case Report.Case reports in surgery · 2026Article
- Comprehensive treatment and surgical features of giant hepatic hemangioma with Kasabach-Merritt syndrome in an adult.Hepatobiliary surgery and nutrition · 2025Article
- Clinical outcomes of combined transarterial chemoembolization and microwave ablation for hepatic hemangiomas: a comparative analysis of large versus. giant tumors.BMC gastroenterology · 2025Article
- Giant hepatic hemangioma in a Japanese adult patient reduced by sirolimus therapy.Clinical journal of gastroenterology · 2025Article
- Efficacy and safety of transcatheter arterial chemoembolization combined with microwave ablation for hepatic hemangiomas (> 5 cm).World journal of gastroenterology · 2025Article
- An enigmatic abdominal mass presenting 1 year after childbirth.Hepatobiliary surgery and nutrition · 2025Article
- Case Report: A rare case of primary hepatic paraganglioma: a mimicker of hepatocellular carcinoma.Frontiers in oncology · 2025Article
- Microwave ablation versus bleomycin-lipiodol emulsion with gelatin sponge embolization for hepatic hemangioma: efficacy and recovery outcomes in a retrospective cohort study.American journal of cancer research · 2025Article
- Case Report: Subcapsular hematoma post-transarterial embolization and its laparoscopic resolution.Frontiers in medicine · 2025Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatic hemangiomas (HHs) are benign liver lesions often discovered incidentally on imaging for various unrelated pathologies. We herein review the etiology, classification, diagnostic imaging, and management of HHs.
methodsA comprehensive systematic review was performed utilizing MEDLINE/PubMed and Web of Science databases, with the end of search date being March 1, 2022, regarding HH diagnosis, imaging, and management.
resultsHHs can be broadly classified as capillary hemangiomas or cavernous hemangiomas. While the exact pathophysiology related to the development of HHs remains largely unknown, hormone exposure has been postulated to cause HH growth. HHs appear homogenously hyperechoic on US with distinct margins and posterior acoustic enhancement. While cavernous hemangiomas appear as well-defined hypodense lesions on pre-contrast CT images with the same density as the vasculature, one of the most reliable imaging features for diagnosing cavernous hemangiomas is high signal intensity on T2 weighted images. While most HHs are asymptomatic, some patients can present with pain or compressive symptoms with bleeding/rupture being very rare. Kasabach-Merritt syndrome is a rare but life-threatening condition associated with thrombocytopenia and microangiopathic hemolytic anemia. When HHs are symptomatic or in the setting of Kasabach Merritt syndrome, surgery is indicated. Enucleation is an attractive surgical option for HH as it spares normal liver tissue. Most patients experience symptom relief following surgical resection.
conclusionHHs are very common benign liver lesions. High-quality imaging is imperative to distinguish HHs from other liver lesions. Surgery is generally reserved for patients who present with symptoms such as pain, obstruction, or rarely Kasabach-Merritt syndrome. Surgery can involve either formal resection or, in most instances, simple enucleation. Patients generally have good outcomes following surgery with resolution of their symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.