Evidence map›Paper›PMID 35705811›Full record

ArticleNature2022

Peptidoglycan maturation controls outer membrane protein assembly.

Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J Knowles, Colin Kleanthous and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  8. Review
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  10. Revealing Cell Envelope Heterogeneity in Two StableInternational journal of molecular sciences · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Gideon Mamou *Department of Biochemistry, South Parks Road, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0897-1680
Federico Corona *Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Ruth Cohen-KhaitDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford, UK.
Nicholas G HousdenDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4706-8278
Vivian YeungDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1200-5533
Dawei SunStructural Biology, Genentech, South San Francisco, CA, USA.
Pooja SridharSchool of Biosciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-7933-7818
Manuel PazosCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-8774-4453
Timothy J KnowlesSchool of Biosciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6632-0985
Colin KleanthousDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford, UK. colin.kleanthous@bioch.ox.ac.uk.ORCID http://orcid.org/0000-0002-3273-0302
Waldemar VollmerCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. waldemar.vollmer@ncl.ac.uk.
University of Oxford · GBUniversity of Birmingham · GBCentre for Life · GBCentro de Biología Molecular Severo Ochoa · ESEuropean Molecular Biology Laboratory · DE

Funding

European Research Council 742555Medical Research Council MR/N002679/1Wellcome TrustWellcome Trust 091911/B/10/ZWellcome Trust 107457/Z/15/ZWellcome Trust 201505/Z/16/Z
6 · The paper itself

Abstract

Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and enable survival in challenging environments

Indexed as

Bacterial Outer Membrane ProteinsCell MembraneEscherichia coliPeptidoglycanCell WallEscherichia coli ProteinsProtein FoldingBacterial Outer Membrane ProteinsEscherichia coli ProteinsPeptidoglycan

Identifiers

PMID35705811
PMCPMC9242858
OpenAlexW4282978620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.