ArticleNature2022
Caspase-7 activates ASM to repair gasdermin and perforin pores.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
82 citing papers in PubMed, 140 citations in OpenAlex.
- Host-microbiota-pathogen interactions drive Salmonella enterica serovar Typhimurium pathogenesis.Nature reviews. Microbiology · 2026Review
- Targeting pyroptosis in intestinal and systemic inflammatory diseases: mechanisms and therapeutic opportunities.Molecular biology reports · 2026Review
- Heparin-binding protein aggravates sepsis-induced acute lung injury by inhibiting the PERK-Nrf2-HO-1 signaling pathway.Journal of molecular histology · 2026Article
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Activating a novel cell death pathway to target PI-resistant multiple myeloma and enhance immunogenic cell death.Apoptosis : an international journal on programmed cell death · 2026Article
- Targeting Gasdermins for Therapeutic Interventions in Central Nervous System Injury.Neurotoxicity research · 2026Review
- Proteolytic activation of executioner caspase-3 and -7 regulates different physiological processes in mice.The EMBO journal · 2026Article
- Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens.Nature microbiology · 2026Review
- Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.Science advances · 2026Article
- Salmonella Effector SpvC Targets SEC23B of Intestinal Epithelial Cells to Resist Gasdermin D-Mediated Protection Against Systemic Infection.Microorganisms · 2026Article
- Alveolar epithelial barrier disruption by FKBP5-mediated necroptosis aggravates lung injury.Respiratory research · 2026Article
- Identification of duck type II interferon-stimulated genes and revelation of duIFI35 inhibition of H5N6 AIV replication by promoting apoptosis.Veterinary research · 2026Article
- Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment.The Journal of experimental medicine · 2026Article
- Apoptotic metabolites synthesize and inherit uniqueBioactive materials · 2026Article
- HIF-1 A-Mediated Lactate Metabolism Confers Ferroptosis Resistance in M1 Macrophages Through Histone Lactylation During Acute Lung Injury.Inflammation · 2026Article
- Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis.Science advances · 2026Article
- Caspase-1 in cancer and inflammatory diseases: a potential therapeutic target.Apoptosis : an international journal on programmed cell death · 2026Review
- Gasdermins against intracellular bacterial pathogens.Nature microbiology · 2026Review
- ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Organelles and cancer cell pyroptosis: overview and perspectives.Cell death & disease · 2025Review
22 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 1 country.
Kengo Nozaki *Department of Immunology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9580-0830
Vivien I Maltez *Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Manira RayamajhiDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alan L TubbsDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Joseph E MitchellDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carolyn A LaceyDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Carissa K HarvestDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Lupeng LiDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
William T NashDepartment of Medicine, Division of Nephrology and the Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.
Heather N LarsonDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Benjamin D McGlaughonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nathaniel J MoormanDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michael G BrownDepartment of Medicine, Division of Nephrology and the Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-2872-7685
Jason K WhitmireDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2578-6073
Edward A MiaoDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA. edward.miao@duke.edu.ORCID http://orcid.org/0000-0001-7295-3490
University of North Carolina at Chapel Hill · USDuke University · USCarter Center · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2MMolecular study of mouse viral resistance mechanisms.R01AI050072 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BROWN, MICHAEL G · 2001 to 2021
$7.1MInnate immune defenses against a cytosolic capsuleR01AI136920 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Edward A Miao · 2019 to 2026
$3.7MRegulation of CD8+ T cell responses to chronic virus infectionR01AI143894 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2019 to 2023
$2.5MIntestinal epithelial cell exfoliation by caspasesR01AI139304 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2MNatural killer cell cytotoxicity against intracellular bacteriaR01AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2MInflammasome Response to Bacterial InfectionR01AI097518 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2012 to 2016
$2.0MObesity associated viral pathogenesisR01AI138337 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2018 to 2022
$1.9MRole of caspase-11 in innate immunityR01AI119073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2015 to 2019
$1.7MAnalyses of the effects of pro-inflammatory cytokines on CD4+ T cell responsesR01AI074862 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2008 to 2012
$1.6MNK cell regulation of adaptive immunity during persisting virus infectionR56AI110682 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2014 to 2014
$380kNCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI050072NIAID NIH HHS R01 AI074862NIAID NIH HHS R01 AI097518NIAID NIH HHS R01 AI119073NIAID NIH HHS R01 AI133236NIAID NIH HHS R01 AI136920NIAID NIH HHS R01 AI138337NIAID NIH HHS R01 AI139304NIAID NIH HHS R01 AI143894NIAID NIH HHS R56 AI110682NIAID NIH HHS R56 AI133236
Abstract
Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin D pores to lyse the cell; however, caspase-1 also activates caspase-7 for unknown reasons
Indexed as
Caspase 7PerforinPhosphate-Binding ProteinsPore Forming Cytotoxic ProteinsSphingomyelin PhosphodiesteraseAnimalsApoptosisChromobacteriumEpithelial CellsGasderminsIntestinesKiller Cells, NaturalListeria monocytogenesMiceOrganoidsT-Lymphocytes, Cytotoxicacid sphingomyelinase-1Casp7 protein, mouseCaspase 7GasderminsGsdmd protein, mousePerforinPhosphate-Binding ProteinsPore Forming Cytotoxic ProteinsSphingomyelin Phosphodiesterase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.