Evidence map›Paper›PMID 35705688›Full record

ArticleScientific reports2022

Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids.

Ting Jiang, Ya-Nan Cao, Jin-Bu Xu, Feng Gao, Ling-Li Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ting JiangDepartment of Pharmacy, The First Afflicted Hospital of Chengdu Medical College, No. 278, Baoguang Rd, Xindu Region, Chengdu, 610500, People's Republic of China.
Ya-Nan CaoSchool of Life Science and Engineering, Southwest Jiaotong University, No. 111, Erhuan Rd, Chengdu, 610031, People's Republic of China.
Jin-Bu XuSchool of Life Science and Engineering, Southwest Jiaotong University, No. 111, Erhuan Rd, Chengdu, 610031, People's Republic of China.
Feng GaoSchool of Life Science and Engineering, Southwest Jiaotong University, No. 111, Erhuan Rd, Chengdu, 610031, People's Republic of China.
Ling-Li ZhengDepartment of Pharmacy, The First Afflicted Hospital of Chengdu Medical College, No. 278, Baoguang Rd, Xindu Region, Chengdu, 610500, People's Republic of China. zhenglingli@cmc.edu.cn.
Southwest Jiaotong University · CNFirst Affiliated Hospital of Chengdu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of new paclitaxel-benzoxazoles hybrids were designed based on both the molecular docking mode of beta-tubulin with paclitaxel derivatives (7a and 7g), and the activity-structure relationship of C-13 side chain in paclitaxel. Palladium-catalyzed direct Csp

Indexed as

Antineoplastic AgentsNeoplasmsBenzoxazolesCatalysisCell Line, TumorCell ProliferationDrug DesignDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructurePaclitaxelPalladiumStructure-Activity RelationshipAntineoplastic AgentsBenzoxazolesPaclitaxelPalladium

Identifiers

PMID35705688
PMCPMC9200075
OpenAlexW4282913825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.