Evidence map›Paper›PMID 35705660›Full record

ArticleScientific reports2022

A novel photosynthetic biologic topical gel for enhanced localized hyperoxygenation augments wound healing in peripheral artery disease.

Yuanjia Zhu, Jinsuh Jung, Shreya Anilkumar, Sidarth Ethiraj, Sarah Madira, Nicholas A Tran, Danielle M Mullis, Kerriann M Casey, Sabrina K Walsh, Charles J Stark and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Towards chlorocytes for therapeutic intravascular photosynthesis.Applied microbiology and biotechnology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Jinsuh JungDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Shreya AnilkumarDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sidarth EthirajDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sarah MadiraDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Nicholas A TranDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Danielle M MullisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kerriann M CaseyDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Sabrina K WalshDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Charles J StarkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Akshay VenkateshDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Alexander BoakyeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.
Stanford University · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
Biomechanical Optimization of Mitral Valve Repair OperationsR01HL152155 · NHLBI · STANFORD UNIVERSITY · PI WOO, Y JOSEPH · 2020 to 2025
$5.9M
NHLBI NIH HHS R01 HL089315NHLBI NIH HHS R01 HL152155NIH HHS R01 HL089315-01
6 · The paper itself

Abstract

Peripheral artery disease and the associated ischemic wounds are substantial causes of global morbidity and mortality, affecting over 200 million people worldwide. Although advancements have been made in preventive, pharmacologic, and surgical strategies to treat this disease, ischemic wounds, a consequence of end-stage peripheral artery disease, remain a significant clinical and economic challenge. Synechococcus elongatus is a cyanobacterium that grows photoautotrophically and converts carbon dioxide and water into oxygen. We present a novel topical biologic gel containing S. elongatus that provides oxygen via photosynthesis to augment wound healing by rescuing ischemic tissues caused by peripheral artery disease. By using light rather than blood as a source of energy, our novel topical therapy significantly accelerated wound healing in two rodent ischemic wound models. This novel topical gel can be directly translated to clinical practice by using a localized, portable light source without interfering with patients' daily activities, demonstrating potential to generate a paradigm shift in treating ischemic wounds from peripheral artery disease. Its novelty, low production cost, and ease of clinical translatability can potentially impact the clinical care for millions of patients suffering from peripheral arterial disease.

Indexed as

Biological ProductsPeripheral Arterial DiseaseGelsHumansIschemiaOxygenPhotosynthesisWound HealingBiological ProductsGelsOxygen

Identifiers

PMID35705660
PMCPMC9200759
OpenAlexW4282914261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.