Evidence map›Paper›PMID 35705592›Full record

ArticleScientific reports2022

Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathway.

Elshazly Mo, Yasmin A Ebedy, Marwa A Ibrahim, Khaled Y Farroh, Eman I Hassanen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elshazly MoPathology Department, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, Egypt.
Yasmin A EbedyPathology Department, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, Egypt.
Marwa A IbrahimBiochemistry Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Khaled Y FarrohNanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Giza, Egypt.
Eman I HassanenPathology Department, Faculty of Veterinary Medicine, Cairo University, P.O. Box 12211, Giza, Egypt. eme_amr@cu.edu.eg.ORCID 0000-0003-3670-6841
Cairo University · EGAgricultural Research Center · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Widespread application of carbendazim (CBZ) is a major environmental impact because of its residues that caused multi-organ dysfunction. Recently, Chitosan nanoparticles (CS-NPs) are extensively used as nanocarriers due to their non-toxic and biodegradable nature. Therefore, the current study aimed to investigate the possible mechanistic pathway of modified CS-NPs to reduce the hepatic and nephrotoxicity of CBZ in rats. CS-NPs were synthesized by the ionic gelation method by using ascorbic acid instead of acetic acid to increase its antioxidant efficiency. Twenty-adult male Wistar rats were grouped (n = 5) as follows: Group (1) negative control, group (2) received CS-NPs, group (3) received CBZ, and group (4) co-administered CS-NPs with CBZ. Rats received the aforementioned materials daily by oral gavage for 28 days and weighed weekly. The results revealed that CBZ receiving group showed severe histopathological alterations in the liver and kidney sections including cellular necrosis and interstitial inflammation confirmed by immunostaining and showed marked immunopositivity of iNOS and caspase-3 protein. There were marked elevations in the serum levels of ALT, AST, urea, and creatinine with a significant increase in MDA levels and decrease in TAC levels. Upregulation of the Keap1 gene and down-regulation of Nrf2 and HO-1 genes were also observed. Co-treatment of rats by CS-NPs with CBZ markedly improved all the above-mentioned toxicological parameters and return liver and kidney tissues to normal histological architecture. We concluded that CBZ caused hepatorenal toxicity via oxidative stress and the Nrf2/HO-1 pathway and CS-NPs could reduce CBZ toxicity via their antioxidant, anti-apoptotic, and anti-inflammatory effects.

Indexed as

ChitosanKidneyLiverNanoparticlesAnimalsAntioxidantsBenzimidazolesCarbamatesHeme Oxygenase-1Kelch-Like ECH-Associated Protein 1MaleMembrane ProteinsNF-E2-Related Factor 2Oxidative StressRatsRats, WistarAntioxidantsBenzimidazolesCarbamatescarbendazimChitosanHeme Oxygenase-1Hmox1 protein, mouseKelch-Like ECH-Associated Protein 1Membrane ProteinsNF-E2-Related Factor 2

Identifiers

PMID35705592
PMCPMC9200826
OpenAlexW4282940635

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.