ArticleNature communications2022
Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Sex-stratified insights into the genetics of brain volumes in late adulthood.Biology of sex differences · 2026Article
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
- Dissecting the shared genetic landscape of schizophrenia and hippocampal subfields: A genome-wide cross-trait analysis.Translational psychiatry · 2026Article
- Integrating genetic regulation and schizophrenia-specific splicing quantitative expression with GWAS prioritizes novel risk genes for schizophrenia.Translational psychiatry · 2025Article
- Beyond volume: Unraveling the genetics of human brain geometry.Science advances · 2025Article
- Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.BMC medicine · 2024Article
- Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale.PLoS biology · 2024Article
- The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders.Nature human behaviour · 2024Article
- Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease.Brain : a journal of neurology · 2024Article
- Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.Nature human behaviour · 2024Article
- Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits.Acta neuropsychiatrica · 2023Article
- The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders.Translational psychiatry · 2023Article
- Polygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress Disorder and Hippocampal Subregion Volumes in Middle Childhood.Behavior genetics · 2023Article
- The genetic architecture of human amygdala volumes and their overlap with common brain disorders.Translational psychiatry · 2023Article
- New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 4 countries.
Funding
Abstract
Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.