Evidence map›Paper›PMID 35705487›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Membrane Stretch Gates NMDA Receptors.

Sophie Belin, Bruce A Maki, James Catlin, Benjamin A Rein, Gabriela K Popescu

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Mechanosensitive receptors in migraine: a systematic review.The journal of headache and pain · 2024
    Pooled it
  2. Electrotherapy in the management of neuropathic corneal pain: narrative review.Experimental biology and medicine (Maywood, N.J.) · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. The neuropathobiology of multiple sclerosis.Nature reviews. Neuroscience · 2024
    Review
  9. Article
  10. Estimating the CaMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. Estimating the CaMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  12. Article
  13. Structural insights into NMDA receptor pharmacology.Biochemical Society transactions · 2023
    Review
  14. Review
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sophie BelinDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214.
Bruce A MakiDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214.
James CatlinDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214.
Benjamin A ReinDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214.
Gabriela K PopescuDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214 popescu@buffalo.edu.ORCID https://orcid.org/0000-0003-4658-2002
University at Buffalo, State University of New York · US

Funding

Probing allosteric surfaces of NMDA receptorsR01NS052669 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2006 to 2015
$3.4M
Experience-Dependent Reorganization of Excitatory Synapse ConnectivityR01MH118298 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAN, JEN QIAN, POPESCU, GABRIELA K · 2019 to 2023
$3.3M
Molecular Physiology of NMDA ReceptorsR35NS132248 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gabriela K Popescu · 2023 to 2026
$2.3M
Gating Mechanism of NMDA ReceptorsR01NS108750 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2019 to 2023
$1.5M
Permeation Mechanisms in NMDA receptorsR01NS097016 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2016 to 2019
$1.4M
Mechanical Activation of NMDA ReceptorsR21NS098385 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI POPESCU, GABRIELA K · 2016 to 2017
$439k
NINDS NIH HHS R01 NS052669NINDS NIH HHS R01 NS097016NINDS NIH HHS R01 NS108750NINDS NIH HHS R21 NS098385NINDS NIH HHS R35 NS132248
6 · The paper itself

Abstract

NMDARs are ionotropic glutamate receptors widely expressed in the CNS, where they mediate phenomena as diverse as neurotransmission, information processing, synaptogenesis, and cellular toxicity. They function as glutamate-gated Ca

Indexed as

Mechanotransduction, CellularReceptors, N-Methyl-D-AspartateAnimalsGlutamic AcidGlycineHumansRatsSynaptic TransmissionGlutamic AcidGlycineReceptors, N-Methyl-D-Aspartateionotropic glutamate receptorsmechanotransductionNMDARspatch-clampsignal transductionsingle-molecule

Identifiers

PMID35705487
PMCPMC9302457
OpenAlexW4282946275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.