Evidence map›Paper›PMID 35705486›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Graded Variation in T1w/T2w Ratio during Adolescence: Measurement, Caveats, and Implications for Development of Cortical Myelin.

Graham L Baum, John C Flournoy, Matthew F Glasser, Michael P Harms, Patrick Mair, Ashley F P Sanders, Deanna M Barch, Randy L Buckner, Susan Bookheimer, Mirella Dapretto and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 81 citations in OpenAlex.

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  11. White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026
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  13. The Fronto-Temporal Cortex Has Increased Subcortical Connectivity In Utero and Plasticity in Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  14. Article
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  16. Article
  17. Two axes of white matter development.Nature communications · 2026
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  18. Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Graham L BaumDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA, 02138 gbaum@fas.harvard.edu.
John C FlournoyDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA, 02138.
Matthew F GlasserDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Michael P HarmsDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Patrick MairDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA, 02138.
Ashley F P SandersDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA, 63110.ORCID https://orcid.org/0000-0002-8834-5489
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA, 63110.ORCID https://orcid.org/0000-0003-1693-8506
Randy L BucknerDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA, 02138.
Susan BookheimerDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA, 90095.
Mirella DaprettoDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA, 90095.
Stephen SmithWellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, OX3 9DU.
Kathleen M ThomasCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA, 55455.
Essa YacoubCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA, 55455.
David C Van EssenDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA, 63110.ORCID https://orcid.org/0000-0001-7044-4721
Leah H SomervilleDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA, 02138.
Harvard University · USWashington University in St. Louis · USUniversity of California, Los Angeles · USUniversity of Minnesota · USUniversity of Oxford · GB

Funding

Mapping the Human Connectome During Typical DevelopmentU01MH109589 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA, BOOKHEIMER, SUSAN Y · 2016 to 2019
$17.1M
RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Connectome Coordination FacilityR24MH108315 · NIMH · WASHINGTON UNIVERSITY · PI MARCUS, DANIEL SCOTT, VAN ESSEN, DAVID C · 2015 to 2019
$5.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Connectome Coordination Facility IIR24MH122820 · NIMH · WASHINGTON UNIVERSITY · PI MARCUS, DANIEL SCOTT, VAN ESSEN, DAVID C · 2020 to 2023
$3.4M
Characterizing pubertal and age mechanisms of neurodevelopment and association with rising internalizing symptomsR01MH129493 · NIMH · HARVARD UNIVERSITY · PI BARCH, DEANNA, SOMERVILLE, LEAH HELENE · 2022 to 2025
$3.4M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
Upgrade Siemens MAGNETOM Trio to MAGNETOM Prisma Fit 3T Human MRI SystemS10OD020039 · OD · HARVARD UNIVERSITY · PI BUCKNER, RANDY L · 2015 to 2015
$600k
NIBIB NIH HHS T32 EB021955NICHD NIH HHS U54 HD087101NIH HHS S10 OD020039NIMH NIH HHS R01 MH060974NIMH NIH HHS R01 MH129493NIMH NIH HHS R24 MH108315NIMH NIH HHS R24 MH122820NIMH NIH HHS T32 MH100019NIMH NIH HHS U01 MH109589
6 · The paper itself

Abstract

Adolescence is characterized by the maturation of cortical microstructure and connectivity supporting complex cognition and behavior. Axonal myelination influences brain connectivity during development by enhancing neural signaling speed and inhibiting plasticity. However, the maturational timing of cortical myelination during human adolescence remains poorly understood. Here, we take advantage of recent advances in high-resolution cortical T1w/T2w mapping methods, including principled correction of B1+ transmit field effects, using data from the Human Connectome Project in Development (HCP-D;

Indexed as

ConnectomeNeocortexAdolescentAdultBayes TheoremChildHumansMagnetic Resonance ImagingMyelin SheathYoung AdultadolescencedevelopmentMRImyelinT1w/T2w

Identifiers

PMID35705486
PMCPMC9302463
OpenAlexW4282933041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.