ArticleBMJ global health2022
The global return on investment from preventing and treating adolescent mental disorders and suicide: a modelling study.
Article in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Economic evaluations of preventive interventions for self-harm and suicide: a systematic review.Psychological medicine · 2026Pooled it
- The intervention effect of internet-based cognitive behavioral therapy on anxiety, depression, and stress in college students: a systematic review and meta-analysis based on randomized controlled trials.Frontiers in psychology · 2026Pooled it
- A systematic review and meta-analysis of diagnostic test accuracy of mental health screening tools applicable to adolescents in sub-Saharan Africa.Frontiers in psychiatry · 2026Pooled it
- The effect of the COVID-19 pandemic and school closures on self-harming and suicidal behaviors in adolescents: A comprehensive meta-analysis.Suicide & life-threatening behavior · 2025Pooled it
- A systematic review of whole disease models for informing healthcare resource allocation decisions.PloS one · 2023Pooled it
- From coordinated services to learning mental health systems: advancing mental healthcare for the 21st century.International journal of mental health systems · 2026Article
- Meeting the challenges to adolescent well-being: context, returns on investment, and financing.Health policy and planning · 2026Article
- The economic case for increased investment in the treatment of adolescents with common mental disorders in Colombia and South Africa.Health policy and planning · 2026Article
- Financing of adolescent health and wellbeing in Bangladesh, Ethiopia and Nigeria: a case study of the Global Financing Facility.BMC global and public health · 2026Article
- Do Psychological Interventions Reduce Paranoia in Adolescents? A Systematic Review.Clinical child and family psychology review · 2026Review
- Development and Evaluation of a University-Based External Coaching Program for School Behavioral Health.Behavioral sciences (Basel, Switzerland) · 2026Article
- Teacher Discipline Intensity and Adolescents' Mental Health Problems: A Moderated Moderation Effect Based on CEPS 2013-2014 Survey Data.Behavioral sciences (Basel, Switzerland) · 2026Article
- Dynamic Network Characteristics of Adolescent Mental Health Symptoms: Gender and Grade Differences Based on a Cross-Lagged Panel Network Model.Behavioral sciences (Basel, Switzerland) · 2026Article
- Child and adolescent psychiatry: challenges, solutions, opportunities, and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Study protocol: role of the blood-brain barrier in stress resilience: investigating new pathways towards Pharmacological augmentation of stress resilience (a PHASR-PP project study).BMC psychology · 2026Article
- Optimising Investment in Health Innovations in Europe.Journal of market access & health policy · 2026Article
- Rethinking Gaming Disorder Prevention: A Socio-Ecological Model Based on Practitioner Insights.International journal of environmental research and public health · 2026Article
- [Adolescent depressive disorder: prevalence, risk factors, current status of diagnosis and treatment, and challenges].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Mental health support in German schools: a cross-sectional survey study of principals on demand vs. provision of support services.Frontiers in public health · 2026Article
- A qualitative exploration of further education college staff perspectives on the challenges and opportunities for using physical activity to support student mental health in England.Discover public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDespite the high burden of mental disorders among adolescents and the potentially lifelong consequences of these conditions, access to mental health services remains insufficient for adolescents in low-income and middle-income countries. We conducted an economic modelling study to quantify the potential costs and benefits of mental health interventions to prevent or treat anxiety, depression, bipolar disorder, and suicide among adolescents.
methodsWe developed a Markov model that followed cohorts of adolescents (ages 10-19) from 36 countries to assess the impact of addressing anxiety, depression, bipolar disorder, and suicide during adolescence on health and non-health outcomes through their lives. We estimated the costs of interventions using an ingredients-based approach and modelled impacts on education and employment and the resulting economic, morbidity, and mortality benefits.
resultsImplementing the selected interventions offers a return on investment of 23.6 and a cost of $102.9 per disability adjusted life year (DALY) averted over 80 years. The high return on investment and low cost per DALY averted is observed across regions and country income levels, with the highest return on investment arising from treating mild depression with group-based cognitive behavioural therapy, prevention of suicide attempts among high-risk adolescents, and universal prevention of combined anxiety and depression in low-income and lower-middle income countries.
conclusionsThe high return on investment and low cost per DALY averted suggests the importance and value of addressing mental disorders among adolescents worldwide. Intervening to prevent and treat these mental disorders even only during adolescence can have lifelong health and economic benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.